Titre :

Sunitinib with concomitant radiation therapy in inoperable sarcomas: Final results from the dose escalation and expansion parts of a multicenter phase I study.

Auteur(s) :

Sunyach, Marie-Pierre [Auteur]
Centre Léon Bérard [Lyon]
Penel, Nicolas [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Service d'oncologie médicale (CHRU Lille)
Montané, Laure [Auteur]
Centre Léon Bérard [Lyon]
Cassier, Philippe A. [Auteur]
Centre Léon Bérard [Lyon]
Largo, Abel Cordoba [Auteur]
Service d'oncologie médicale (CHRU Lille)
Sargos, P. [Auteur]
Institut Bergonié [Bordeaux]
Blanc, Ellen [Auteur]
Centre Léon Bérard [Lyon]
Pérol, David [Auteur]
Centre Léon Bérard [Lyon]
Blay, Jean-Yves [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Centre Léon Bérard [Lyon]

Titre de la revue :

Radiotherapy & Oncology

Nom court de la revue :

Radiother Oncol

Date de publication :

2022-01-26

ISSN :

1879-0887

Mot(s)-clé(s) en anglais :

Inoperable non-GIST Sarcomas
Sunitinib
Radiation therapy
Escalation phase I study
Tyrosine kinase inhibitor
Combined treatment

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Introduction Local control in sarcoma is rarely achieved with exclusive radiotherapy (RT). We aim to assess the feasibility and safety of sunitinib continuously administrated with concomitant RT in inoperable non-GIST ...
Lire la suite >Introduction Local control in sarcoma is rarely achieved with exclusive radiotherapy (RT). We aim to assess the feasibility and safety of sunitinib continuously administrated with concomitant RT in inoperable non-GIST sarcomas patients. Methods This multicentric French 3 + 3 dose escalation study included patients with inoperable locally advanced or recurrent sarcoma, ECOG-PS <2, ≤2 metastatic sites and no brain metastases, adequate organ functions and absence of uncontrolled hypertension, who had never received sunitinib or radiotherapy. The escalation phase planned to use sunitinib dose levels (DL1: 25; DL2: 37.5; DL3: 50 mg/day) with standard RT (60 Gy, 30 fractions, 5 fractions/week/6 weeks). The primary endpoint was to determine the incidence of dose-limiting toxicities (DLT) in the first 14 weeks and the maximal tolerated dose (MTD). Secondary endpoints included safety (acute and late toxicities), local control at 6 months including local progression free rate (L-PFR) progression free survival (PFS), overall survival (OS), proportion of patients eligible for surgery after treatment. Results From May 2011 to April 2016, the dose-escalation phase enrolled 10 patients (DL1 N = 4; DL2 N = 6). No DLT was observed in at DL1. One DLT (grade 4 thrombopenia) occurred at DL2. The 19 patients treated at DL2 (including the 13 patients from the expansion phase) received sunitinib for a median duration of 42.7 (2.8–79.1) days, and radiotherapy for 6.4 (1–8) weeks; all but 3 patients received 60 Gy (40 Gy, early progression (N = 1); 8 Gy, early death (N = 1), prescribed dose, 50 Gy (N = 1)). With a median follow-up of 19.5 (14–36.5) months, the median PFS was 6.5 (1.9–31.1) months. Median OS was not reached. At 6 months, L-PFR was 73.3% (95%CI 44.9%-92.2%). One patient was amendable to surgery after treatment. Sunitinib-related grade ≥ 3 adverse events occurred in 58% of the patients treated at DL2 (Escalation N = 4; Expansion N = 7). Seven (36.8%) deaths related to disease progression were reported. Conclusion This is the first trial assessing the combination of continuous administration of sunitinib 37.5 mg with exclusive RT in non-GIST sarcoma. Whereas this combination was found feasible, efficient, further investigations of combinations of more recent multikinase inhibitors with RT need to be explored.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CHU Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Date de dépôt :

2023-11-15T05:06:47Z
2024-01-15T09:59:25Z