Titre :

Pediatric Sepsis Biomarker Risk Model With Outcome After PICU Discharge: A Strong Research Tool, but Let Us Not Forget Composite Prognostic Factors!

Auteur(s) :

Leteurtre, Stephane [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Recher, Morgan [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]

Titre de la revue :

Pediatric Critical Care Medicine

Nom court de la revue :

Pediatr Crit Care Med

Numéro :

22

Pagination :

p. 125-127

Date de publication :

2021-01

ISSN :

1529-7535

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

OBJECTIVE: The Life after Pediatric Sepsis Evaluation (LAPSE) investigation recently reported that one third of children who survive sepsis experience significant health-related quality of life (HRQL) impairment compared ...
Lire la suite >OBJECTIVE: The Life after Pediatric Sepsis Evaluation (LAPSE) investigation recently reported that one third of children who survive sepsis experience significant health-related quality of life (HRQL) impairment compared to baseline at one year after hospitalization. PERSEVERE is a multi-biomarker tool for estimating baseline risk of mortality among children with septic shock. We determined if the PERSEVERE biomarkers have predictive capacity for estimating the risk of hospital mortality and long-term HRQL morbidity among children with community-acquired septic shock. DESIGN: Secondary analysis. SETTING: Twelve academic pediatric intensive care units. PATIENTS: A subset of LAPSE subjects (n = 173) with available blood samples. INTERVENTIONS: None MEASUREMENTS AND MAIN RESULTS: Three predefined outcomes from the LAPSE investigation were evaluated: all-cause hospital mortality (n = 173), and the composite outcome of mortality or Persistent, Serious Deterioration of HRQL (PSD-HRQL; > 25% below baseline) among surviving children at 1 month (n = 125) or 3 months (n = 117). PERSEVERE had an AUROC of 0.73 (95% C.I. 0.59 to 0.87; p = 0.002) for estimating the risk of hospital mortality and was independently associated with increased odds of hospital mortality. In multivariable analyses, PERSEVERE was not independently associated with increased odds of the composite outcome of mortality or deterioration of PSD-HRQL > 25% below baseline. A new decision tree utilizing the PERSEVERE biomarkers had an AUROC of 0.87 (95% C.I. 0.80 to 0.95) for estimating the risk of PSD-HRQL at 3 months among children who survived septic shock. CONCLUSIONS: PERSEVERE had modest performance for estimating hospital mortality in an external cohort of children with community acquired septic shock. The PERSEVERE biomarkers appear to have utility for estimating the risk of PSD-HRQL up to three months after surviving septic shock. These findings suggest an opportunity to develop a clinical tool for early assignment of risk for long term HRQL morbidity among children who survive septic shock.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CHU Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Date de dépôt :

2023-11-15T07:23:45Z
2024-02-08T13:46:45Z