Titre :

Nasal chemosensory tests: biomarker between dementia with Lewy bodies and Parkinson disease dementia.

Auteur(s) :

Foguem, Clovis [Auteur]
Lemdani, Mohamed [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Huart, Caroline [Auteur]
Cliniques Universitaires Saint-Luc [Bruxelles]

Titre de la revue :

Rhinology

Nom court de la revue :

Rhinology

Date de publication :

2020-08-29

ISSN :

0300-0729

Mot(s)-clé(s) en anglais :

biomarker
dementia with Lewy bodies
differential diagnosis
odor detection thresholds
Parkinson disease dementia

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Background: Dementia with Lewy bodies (DLB) and Parkinson disease dementia (PDD) are progressive and disabling neurode-generative disorders, which are often misdiagnosed due to theirs overlapping clinical and paraclinical ...
Lire la suite >Background: Dementia with Lewy bodies (DLB) and Parkinson disease dementia (PDD) are progressive and disabling neurode-generative disorders, which are often misdiagnosed due to theirs overlapping clinical and paraclinical features. Nevertheless, their adequate management requires an accurate differential diagnosis. The main aim of this study was to investigate the usefulness of olfactory and trigeminal nasal testing for the differential diagnosis between DLB and PDD. Methods: Odor thresholds to three odorants differentially activating the olfactory and trigeminal systems were assessed in patients with DLB, PDD and healthy controls (n = 20 per group). Results: Odor thresholds were significantly different between the three groups of subjects. More precisely, we found that DLB patients had significantly lower detection threshold performances compared to PDD patients. Moreover, using a standard canonical discriminant analysis, we confirmed a plain differentiation between the three groups. Conclusions: The current study highlights that DLB patients have very poor olfactory and trigeminal detection threshold performances, which are significantly lower, compared to PDD patients. These results suggest that olfactory testing, using odorants that stimulate both the olfactory and trigeminal systems, could constitute an interesting biomarker and contribute to the differential diagnosis of PDD and DLB patients. Further researches, notably on olfacto-trigeminal interactions, are warranted in these popula-tions to support our findings.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CHU Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Date de dépôt :

2023-11-15T08:17:13Z
2023-12-08T14:43:17Z