Title :

Aggregate and cumulative chronic risk assessment for pyrethroids in the French adult population

Author(s) :

Vanacker, M. [Auteur]
Quindroit, Paul [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Angeli, K. [Auteur]
Mandin, C. [Auteur]
Glorennec, P. [Auteur]
Brochot, C. [Auteur]
Crepet, A. [Auteur]

Journal title :

Food and Chemical Toxicology

Abbreviated title :

Food Chem. Toxicol.

Volume number :

143

Pages :

111519

Publication date :

2020-09

ISSN :

0278-6915

English keyword(s) :

Cumulative aggregate exposure
Pesticides
Neurotoxicity
Environmental health
Diet
Physiologically based pharmacokinetic model

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Pyrethroids are commonly used as insecticides in households, in agriculture or in veterinary and medicinal products. This study aimed to assess cumulative aggregate exposure to cyfluthrin, cypermethrin, deltamethrin and ...
Show more >Pyrethroids are commonly used as insecticides in households, in agriculture or in veterinary and medicinal products. This study aimed to assess cumulative aggregate exposure to cyfluthrin, cypermethrin, deltamethrin and permethrin in adults in France and the associated health risk, and to identify major contributions of exposure sources and routes. External chronic exposures were estimated from dietary and several environmental sources for the oral, inhalation and dermal routes. Internal concentrations of five associated metabolites were simulated with a physiologically-based pharmacokinetic model. The predicted urinary concentrations were in same order of magnitude as those of the French ENNS biomonitoring survey. Dietary exposure, especially from cereals and animal products, was the major source of exposure. For the 1% of adults most highly exposed, dermal exposure to permethrin through medicinal and veterinary products was an important source of exposure. Considering alterations of motor, sensory and autonomic division, all individual margins of exposure were higher than 100, suggesting that no neurotoxic risk associated with the cumulative aggregate exposure to these four pyrethroids is expected for the French adult population.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2023-11-15T08:34:12Z
2024-03-26T10:24:08Z