Titre :

Glycemic index, glycemic load, and risk of coronary heart disease: a pan-European cohort study.

Auteur(s) :

Sieri, Sabina [Auteur]
IRCCS Istituto Nazionale dei Tumori [Milano]
Agnoli, Claudia [Auteur]
IRCCS Istituto Nazionale dei Tumori [Milano]
Grioni, Sara [Auteur]
IRCCS Istituto Nazionale dei Tumori [Milano]
Weiderpass, Elisabete [Auteur]
Centre International de Recherche contre le Cancer - International Agency for Research on Cancer [CIRC - IARC]
Mattiello, Amalia [Auteur]
University of Naples Federico II = Università degli studi di Napoli Federico II
Sluijs, Ivonne [Auteur]
Julius Center for Health Sciences and Primary Care
Sanchez, Maria Jose [Auteur]
Andalusian School of Public Health [Granada]
Jakobsen, Marianne Uhre [Auteur]
Danmarks Tekniske Universitet = Technical University of Denmark [DTU]
Sweeting, Michael [Auteur]
University of Cambridge [UK] [CAM]
Van Der Schouw, Yvonne T. [Auteur]
Julius Center for Health Sciences and Primary Care
Nilsson, Lena Maria [Auteur]
Umeå University Hospital = Norrlands universitetssjukhus [Nus]
Wennberg, Patrik [Auteur]

Katzke, Verena A. [Auteur]
German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] [DKFZ]
Kühn, Tilman [Auteur]
German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] [DKFZ]
Overvad, Kim [Auteur]
Aarhus University [Aarhus]
Tong, Tammy Y. N. [Auteur]
University of Oxford
Conchi, Moreno-Iribas [Auteur]
Universidad de Navarra [Pamplona] [UNAV]
Quirós, José Ramón [Auteur]
García-Torrecillas, Juan Manuel [Auteur]
Universidad de Almería [UAL]
Mokoroa, Olatz [Auteur]

Gómez, Jesús-Humberto [Auteur]
Universidad de Murcia
Tjønneland, Anne [Auteur]
Department of Public Health [Copenhagen]
Sonestedt, Emiliy [Auteur]
Lund University
Trichopoulou, Antonia [Auteur]
Hellenic Health Foundation
Karakatsani, Anna [Auteur]
Hellenic Health Foundation
Valanou, Elissavet [Auteur]
Hellenic Health Foundation
Boer, Jolanda M. A. [Auteur]
National Institute for Public Health and the Environment [Bilthoven] [RIVM]
Verschuren, W. Monique M. [Auteur]
National Institute for Public Health and the Environment [Bilthoven] [RIVM]
Boutron-Ruault, Marie-Christine [Auteur]
Centre de recherche en épidémiologie et santé des populations [CESP]
Fagherazzi, Guy [Auteur]
Centre de recherche en épidémiologie et santé des populations [CESP]
Madika, Anne-Laure [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Bergmann, Manuela M. [Auteur]
German Institute of Human Nutrition Potsdam-Rehbrücke [DIfE]
Schulze, Matthias B. [Auteur]
University of Potsdam = Universität Potsdam
Ferrari, Pietro [Auteur]
International Agency for Cancer Research [IACR]
Freisling, Heinz [Auteur]
International Agency for Cancer Research [IACR]
Lennon, Hannah [Auteur]
Centre International de Recherche contre le Cancer - International Agency for Research on Cancer [CIRC - IARC]
Sacerdote, Carlotta [Auteur]
Azienda Ospedalerio - Universitaria Città della Salute e della Scienza di Torino = University Hospital Città della Salute e della Scienza di Torino
Masala, Giovanna [Auteur]
Tumino, Rosario [Auteur]
Civile - M.P.Arezzo Hospital
Riboli, Elio [Auteur]
Imperial College London
Wareham, Nicholas J. [Auteur]
University of Cambridge [UK] [CAM]
Danesh, John [Auteur]
University of Cambridge [UK] [CAM]
Forouhi, Nita G. [Auteur]
University of Cambridge [UK] [CAM]
Butterworth, Adam S. [Auteur]
University of Cambridge [UK] [CAM]
Krogh, Vittorio [Auteur]
IRCCS Istituto Nazionale dei Tumori [Milano]

Titre de la revue :

The American Journal of Clinical Nutrition

Nom court de la revue :

Am. J. Clin. Nutr.

Numéro :

112

Pagination :

631-643

Date de publication :

2020-07-04

ISSN :

1938-3207

Mot(s)-clé(s) en anglais :

glycemic index
glycemic load
coronary heart disease
cohort study
EPIC study
EPIC-CVD study

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Background High carbohydrate intake raises blood triglycerides, glucose, and insulin; reduces HDLs; and may increase risk of coronary heart disease (CHD). Epidemiological studies indicate that high dietary glycemic index ...
Lire la suite >Background High carbohydrate intake raises blood triglycerides, glucose, and insulin; reduces HDLs; and may increase risk of coronary heart disease (CHD). Epidemiological studies indicate that high dietary glycemic index (GI) and glycemic load (GL) are associated with increased CHD risk. Objectives The aim of this study was to determine whether dietary GI, GL, and available carbohydrates are associated with CHD risk in both sexes. Methods This large prospective study—the European Prospective Investigation into Cancer and Nutrition—consisted of 338,325 participants who completed a dietary questionnaire. HRs with 95% CIs for a CHD event, in relation to intake of GI, GL, and carbohydrates, were estimated using covariate-adjusted Cox proportional hazard models. Results After 12.8 y (median), 6378 participants had experienced a CHD event. High GL was associated with greater CHD risk [HR 1.16 (95% CI: 1.02, 1.31) highest vs. lowest quintile, p-trend 0.035; HR 1.18 (95% CI: 1.07, 1.29) per 50 g/day of GL intake]. The association between GL and CHD risk was evident in subjects with BMI (in kg/m2) ≥25 [HR: 1.22 (95% CI: 1.11, 1.35) per 50 g/d] but not in those with BMI <25 [HR: 1.09 (95% CI: 0.98, 1.22) per 50 g/d) (P-interaction = 0.022). The GL–CHD association did not differ between men [HR: 1.19 (95% CI: 1.08, 1.30) per 50 g/d] and women [HR: 1.22 (95% CI: 1.07, 1.40) per 50 g/d] (test for interaction not significant). GI was associated with CHD risk only in the continuous model [HR: 1.04 (95% CI: 1.00, 1.08) per 5 units/d]. High available carbohydrate was associated with greater CHD risk [HR: 1.11 (95% CI: 1.03, 1.18) per 50 g/d]. High sugar intake was associated with greater CHD risk [HR: 1.09 (95% CI: 1.02, 1.17) per 50 g/d]. Conclusions This large pan-European study provides robust additional support for the hypothesis that a diet that induces a high glucose response is associated with greater CHD risk.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CHU Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Date de dépôt :

2023-11-15T08:34:32Z
2023-12-19T09:24:48Z