Title :

Hematogenous osteomyelitis in childhood can relapse many years later into adulthood: A retrospective multicentric cohort study in France.

Author(s) :

Clerc, Axelle [Auteur]
Hôpital de la Croix-Rousse [CHU - HCL]
Zeller, Valérie [Auteur]
Groupe Hospitalier Diaconesses Croix Saint-Simon
Marmor, Simon [Auteur]
Groupe Hospitalier Diaconesses Croix Saint-Simon
Senneville, Eric [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Marchou, Bruno [Auteur]
Service Maladies infectieuses et tropicales [CHU Toulouse]
Laurent, Frederic [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Lucht, Frederic [Auteur]
Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] [CHU ST-E]
Desplaces, Nicole [Auteur]
Groupe Hospitalier Diaconesses Croix Saint-Simon
Lustig, Sebastien [Auteur]
Hôpital de la Croix-Rousse [CHU - HCL]
Chidiac, Christian [Auteur]
Service de Maladies Infectieuses et Tropicales [Hôpital de la Croix-Rousse - HCL]
Ferry, Tristan [Auteur]
Service de Maladies Infectieuses et Tropicales [Hôpital de la Croix-Rousse - HCL]

Journal title :

Bulletin of the School of Medicine (Baltimore, Md.)

Abbreviated title :

Medicine (Baltimore)

Volume number :

99

Pages :

e19617

Publication date :

2020-06-06

ISSN :

1536-5964

English keyword(s) :

adulthood
hematogenous osteomyelitis
relapse
Staphylococcus aureus

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

To describe the epidemiological, clinical, laboratory, and radiological features and the management of adult patients who experienced a relapse between 2003 and 2015 of an acute hematogenous osteomyelitis acquired in ...
Show more >To describe the epidemiological, clinical, laboratory, and radiological features and the management of adult patients who experienced a relapse between 2003 and 2015 of an acute hematogenous osteomyelitis acquired in childhood. A retrospective multicentric cohort study was conducted in 5 centers in France. Thirty-seven patients were included. The median age was 40 years (28–56), and 26 (70%) were male. The first site of infection was the distal femur (n = 23, 62%). The median time between the osteomyelitis in childhood and the relapse in adulthood was 26 years (13–45). Thirty-four (92%) patients reported inflammatory local clinical manifestations, 17 (46%) draining fistula, 10 (27%) fever. Most patients had intramedullary gadolinium deposition (with or without abscess) on magnetic resonance imaging. Most relapses were monomicrobial infections (82%). Staphylococcus aureus was the most commonly found microorganism (82%), expressing a small colony variant phenotype in 3 cases. Most patients (97%) had a surgical treatment, and the median duration of antibiotics for the relapse was 12 weeks. All patients had a favorable outcome, no patient died and no further relapse occurred. We count 2 femoral fractures on osteotomy site. Osteomyelitis in childhood can relapse later in adulthood, especially in patients with lack of care during the initial episode. Osteotomy and prolonged antimicrobial therapy are required for clinical remission.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2023-11-15T08:50:24Z
2023-12-15T10:02:07Z