Titre :

Two-Layered Susceptibility vessel sign is associated with biochemically quantified thrombus red blood cell content.

Auteur(s) :

Di Meglio, Lucas [Auteur]
Laboratoire de Recherche Vasculaire Translationnelle [LVTS (UMR_S_1148 / U1148)]
Derraz, Imad [Auteur]
Neuroradiologie [Hôpital Gui de Chauliac]
Solonomenjanahary, Mialitiana [Auteur]
Laboratoire de Recherche Vasculaire Translationnelle [LVTS (UMR_S_1148 / U1148)]
Daly, D. [Auteur]
Neuroradiologie [Hôpital Gui de Chauliac]
Filho, Salomão Faroj Chodraui [Auteur]
CHU Rothschild [AP-HP]
Maacha, Malek Ben [Auteur]
Hôpital de la Fondation Ophtalmologique Adolphe de Rothschild [AP-HP]
Labreuche, Julien [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Desal, Hubert [Auteur]
Hôpital Guillaume-et-René-Laennec [Saint-Herblain]
Consoli, Arturo [Auteur]
Hôpital Foch [Suresnes]
Lapergue, Bertrand [Auteur]
Hôpital Foch [Suresnes]
Blanc, Raphael [Auteur]
Laboratoire de Recherche Vasculaire Translationnelle [LVTS (UMR_S_1148 / U1148)]
Piotin, Michel [Auteur]
Laboratoire de Recherche Vasculaire Translationnelle [LVTS (UMR_S_1148 / U1148)]
Mazighi, Mikael [Auteur]
Laboratoire de Recherche Vasculaire Translationnelle [LVTS (UMR_S_1148 / U1148)]
Ho-Tin-Noé, Benoit [Auteur]
Laboratoire de Recherche Vasculaire Translationnelle [LVTS (UMR_S_1148 / U1148)]
Desilles, Jean Philippe [Auteur]
Laboratoire de Recherche Vasculaire Translationnelle [LVTS (UMR_S_1148 / U1148)]
Bourcier, Romain [Auteur]
Hôpital Guillaume-et-René-Laennec [Saint-Herblain]
Daly, D. [Auteur]

Titre de la revue :

European Journal of Neurology

Nom court de la revue :

Eur. J. Neurol.

Numéro :

27

Pagination :

1264-1271

Date de publication :

2020-04-04

ISSN :

1468-1331

Mot(s)-clé(s) en anglais :

acute stroke
endovascular treatment
predictors

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Background and purpose Better characterization of the thrombus could be useful to determine acute ischaemic stroke (AIS) aetiology and predict response to thrombolysis and endovascular therapy (EVT). To test the hypothesis ...
Lire la suite >Background and purpose Better characterization of the thrombus could be useful to determine acute ischaemic stroke (AIS) aetiology and predict response to thrombolysis and endovascular therapy (EVT). To test the hypothesis that susceptibility vessel sign (SVS) on baseline magnetic resonance imaging (MRI) is related to red blood cell (RBC) content of AIS thrombi, the total haemoglobin contents (HbCs) of AIS thrombi retrieved by EVT from patients with or without SVS or two-layered SVS (TLSVS) were compared. Methods Baseline MRI of 84 anterior AIS patients was reviewed by neuro-radiologists blinded to clinical and biochemical data. Thrombi from these patients were retrieved by EVT and analysed for HbC by quantitative enzyme-linked immunosorbent assay and measurement of haem concentration. Results Susceptibility vessel sign and TLSVS were respectively observed in 85.7% and 50.0% of cases. The median HbC content was 253 µg/mg thrombus (interquartile range 177–333) and the median haem content was 219 µg/mg thrombus (131–264). Thrombus HbC and haem content were highly correlated with thrombus RBC content determined by flow cytometry (r = 0.94). Thrombi from patients with TLSVS weighed more [31.1 (16.5–68.3) mg vs. 17.7 (11.7–33.3) mg; P = 0.005] and had a higher HbC content [278 (221–331) µg/mg vs. 196 (139–301) µg/mg; P = 0.010] compared to thrombi from patients without TLSVS. There was no difference in thrombus weight or HbC content according to SVS status. Conclusions Our study shows that TLSVS is significantly associated with a higher thrombus weight and RBC content, as determined by quantitative assays.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CHU Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Date de dépôt :

2023-11-15T09:04:21Z
2023-12-15T08:02:07Z