Title :

A prospective pilot study of the T-lymphocyte response to fine particulate matter exposure.

Author(s) :

Al Zallouha, Margueritta [Auteur]
Unité de Chimie Environnementale et Interactions sur le Vivant [UCEIV]
Landkocz, Yann [Auteur]
Unité de Chimie Environnementale et Interactions sur le Vivant [UCEIV]
Méausoone, Clémence [Auteur]
Unité de Chimie Environnementale et Interactions sur le Vivant [UCEIV]
Ledoux, Frédéric [Auteur]
Unité de Chimie Environnementale et Interactions sur le Vivant [UCEIV]
Visade, Fabien [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Cazier, Fabrice [Auteur]
Université du Littoral Côte d'Opale [ULCO]
Martin, Perrine J. [Auteur]
Unité de Chimie Environnementale et Interactions sur le Vivant [UCEIV]
Borgie, Mireille [Auteur]
Unité de Chimie Environnementale et Interactions sur le Vivant [UCEIV]
Vitagliano, Jean-Jacques [Auteur]
Groupement des Hôpitaux de l'Institut Catholique de Lille [GHICL]
Trémolet, Gautier [Auteur]
Unité de Chimie Environnementale et Interactions sur le Vivant [UCEIV]
Cailliez, Jean-Charles [Auteur]
Institut Catholique de Lille [ICL]
Gosset, Pierre [Auteur]
Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017
Courcot, Dominique [Auteur]
Unité de Chimie Environnementale et Interactions sur le Vivant [UCEIV]
Billet, Sylvain [Auteur]
Unité de Chimie Environnementale et Interactions sur le Vivant [UCEIV]

Journal title :

Journal of Applied Toxicology

Abbreviated title :

J Appl Toxicol

Volume number :

40

Pages :

619-630

Publication date :

2020-01-27

ISSN :

1099-1263

English keyword(s) :

age
air pollution
fine particulate matter
immunological profile
metabolic activation
T lymphocytes

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Exposure to air pollution is associated with increased morbidity and mortality. Once the fine atmospheric particulate matter (FP) is inhaled, some of its compounds can pass through the lungs and reach the bloodstream where ...
Show more >Exposure to air pollution is associated with increased morbidity and mortality. Once the fine atmospheric particulate matter (FP) is inhaled, some of its compounds can pass through the lungs and reach the bloodstream where they can come into contact with immune cells. Exposure to FP particularly affects sensitive populations such as the elderly. Aging affects the immune system, making the elderly more vulnerable. The project aims to determine the effects of FP exposure on human T cells while looking for biomarkers associated with exposure. Blood samples from 95 healthy subjects in three different age groups (20-30, 45-55 and 70-85 years) were collected to determine a potential age effect. T lymphocytes were isolated to be exposed ex vivo for 72 hours to 45 μg/mL of FP collected in Dunkirk and chemically characterized. Overexpression of the CYP1A1, CYP1B1 and CYP2S1 genes was therefore measured after exposure of the T cells to FP. These genes code for enzymes known to be involved in the metabolic activation of organic compounds such as polycyclic aromatic hydrocarbons detected in the FP sample. T-cell profiling allowed us to suggest a mixed T-helper 1/2 profile caused by exposure to FP. With regard to the influence of age, we have observed differences in the expression of certain genes, as well as an increase in interleukin-4 and -13 concentrations in the elderly. These results showed that exposure of T lymphocytes to FP causes effects on both transcriptomic and cytokine secretion levels.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille

Collections :

• Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017
• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2023-11-15T09:31:11Z
2024-01-10T13:58:52Z
2024-01-10T14:00:30Z