Title :

A current overview of the pharmacological composition of “La Chimique” consumed in Mayotte: Preliminary results of the CHASSE-MAREE protocol

Author(s) :

Richeval, Camille [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Gish, Alexandr [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Cottereau, Victoire [Auteur]
Centre Universitaire de Formation et de Recherche de Mayotte (CUFR) [CUFR]
Peyre, Alexandre [Auteur]
Pleignet, Eric [Auteur]
Cherki, Sabrina [Auteur]
Allorge, Delphine [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Gaulier, Jean-Michel [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Devault, Damien A. [Auteur]
Centre Universitaire de Formation et de Recherche de Mayotte (CUFR) [CUFR]

Journal title :

Drug Testing Analysis

Abbreviated title :

Drug Test Anal

Publisher :

Wiley

Publication date :

2023-10-06

ISSN :

1942-7611

English keyword(s) :

\"La Chimique\"
LC-HRMS
Mayotte
synthetic cannabinoids

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Mayotte Island, a French department located in the Mozambique Channel, has for several years been faced with the consumption of “La Chimique” (LC), reputed (but extremely poorly documented) to be a mixture of tobacco and ...
Show more >Mayotte Island, a French department located in the Mozambique Channel, has for several years been faced with the consumption of “La Chimique” (LC), reputed (but extremely poorly documented) to be a mixture of tobacco and synthetic cannabinoid receptor agonists (SCRAs). One of the objectives of the CHASSE-MAREE protocol is to assess the composition and heterogeneity of LC products through successive LC sample collection campaigns among users. Currently underway, we present here the first analytical results (samples collected in 2022). Between September and December 2022, 80 samples were collected throughout the island over three periods: 70 in the usual form of LC (small folded papers containing a plant-like sample, mostly tobacco), 6 powders, and 4 cigarettes. Analysis was performed using liquid chromatography with high-resolution mass spectrometry. The detected substances (number of detections) included SCRAs (MDMB-4en-PINACA [35], ADB-FUBIATA [25], MDMB-INACA [16], ADB-BUTINACA [15], AFUBIATA [11], 4F-MDMD-BICA [7], CH-PIATA [14], 5C-APINACA [3], BZO-HEXOXIZID [2], and 4F-ABINACA [1]), nicotine (68), tetrahydrocannabinol (THC), cannabinol (CBN), and cannabidiol (CBD) (2), medications (amantadine [11], cyamemazine [6], and acetaminophen [3]), and a designer benzodiazepine (bromazolam [4]). The SCRAs currently in use are varied, and the market for “cooks” (those who prepare LC) is dispersed according to where and when samples are collected. These preliminary results will be supplemented by analysis of samples collected in the first half of 2023 and by an improved description of the current panorama of consumption of LC in Mayotte (mapping, effects felt and dependence, etc.).Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille
Institut Pasteur de Lille

Collections :

• IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483

Submission date :

2023-11-17T04:21:25Z
2023-12-13T11:01:23Z