Title :

How Osmoviscoelastic Coupling Affects Recovery of Cyclically Compressed Intervertebral Disc.

Author(s) :

Feki, F. [Auteur]
Taktak, R. [Auteur]
Kandil, K. [Auteur]
Derrouiche, A. [Auteur]
Moulart, M. [Auteur]
Haddar, N. [Auteur]
Zairi, Fahmi [Auteur]
Laboratoire Génie Civil et géo-Environnement (LGCgE) - ULR 4515
Zairi, Fahed [Auteur]
Hôpital Privé Le Bois Ramsay Santé [Lille]

Journal title :

Spine

Abbreviated title :

Spine (Phila Pa 1976)

Volume number :

45

Pages :

E1376-E1385

Publication date :

2020-10-10

ISSN :

1528-1159

English keyword(s) :

recovery
osmoviscoelastic mechanisms
intervertebral disc
fluid flow
chemomechanical coupling
axial cyclic loading

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Study Design. Osmoviscoelastic behavior of cyclically loaded cervical intervertebral disc. Objective. The aim of this study was to evaluate in vitro the effects of physiologic compressive cyclic loading on the ...
Show more >Study Design. Osmoviscoelastic behavior of cyclically loaded cervical intervertebral disc. Objective. The aim of this study was to evaluate in vitro the effects of physiologic compressive cyclic loading on the viscoelastic properties of cervical intervertebral disc and, examine how the osmoviscoelastic coupling affects time-dependent recovery of these properties following a long period of unloading. Summary of Background Data. The human neck supports repetitive loadings during daily activities and recovery of disc mechanics is essential for normal mechanical function. However, the response of cervical intervertebral disc to cyclic loading is still not very well defined. Moreover, how loading history conditions could affect the time-dependent recovery is still unclear. Methods. Ten thousand cycles of compressive loading, with different magnitudes and saline concentrations of the surrounding fluid bath, are applied to 8 motion segments (composed by 2 adjacent vertebrae and the intervening disc) extracted from the cervical spines of mature sheep. Subsequently, specimens are hydrated during 18 hours of unloading. The viscoelastic disc responses, after cyclic loading and recovery phase, are characterized by relaxation tests. Results. Viscoelastic behaviors are significantly altered following large number of cyclic loads. Moreover, after 18-hour recovery period in saline solution at reference concentration (0.15 mol/L), relaxation behaviors were fully restored. Nonetheless, full recovery is not obtained whether the concentration of the surrounding fluid, that is, hypo-, iso-, or hyper-osmotic conditions. Conclusion. Cyclic loading effects and full recovery of viscoelastic behavior after hydration at iso-osmotic condition (0.15 mol/L) are governed by osmotic attraction of fluid content in the disc due to imbalance between the external load and the swelling pressure of the disc. After removal of the load, the disc recovers its viscoelastic properties following period of rest. Nevertheless, the viscoelastic recovery is a chemically activated process and its dependency on saline concentration is governed by fluid flow due to imbalance of ions between the disc tissues and the surrounding fluid.Show less >

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192

Submission date :

2023-12-13T05:15:03Z
2024-01-31T10:53:11Z