Titre :

Hypothalamic neuroglial plasticity is regulated by anti-Müllerian hormone and disrupted in polycystic ovary syndrome.

Auteur(s) :

Barbotin, Anne-Laure [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Mimouni, Nour El Houda [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Kuchcinski, Gregory [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Viard, Romain [Auteur]
Lille in vivo imaging and Functional Exploration - PLBS [LiiFE]
Rasika, Sowmyalakshmi [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Mazur, Danièle [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Mauro, Silva [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Simon, Virginie [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Boursier, Angele [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Pruvo, Jean-Pierre [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Yu, Q. [Auteur]
Candlish, M. [Auteur]
Boehm, U. [Auteur]
Bello, F. D. [Auteur]
Medana, C. [Auteur]
Pigny, Pascal [Auteur]
Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277
Dewailly, Didier [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Prevot, Vincent [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Jonard-Catteau, Sophie [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Giacobini, Paolo [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172

Titre de la revue :

EBioMedicine

Nom court de la revue :

EBioMedicine

Numéro :

90

Pagination :

104535

Date de publication :

2023-04

ISSN :

2352-3964

Mot(s)-clé(s) en anglais :

PCOS
AMH
GnRH
Tanycytes
MR spectroscopy
Hypothalamus

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Background Polycystic ovary syndrome (PCOS) is the most common reproductive-endocrine disorder affecting between 5 and 18% of women worldwide. An elevated frequency of pulsatile luteinizing hormone (LH) secretion and ...
Lire la suite >Background Polycystic ovary syndrome (PCOS) is the most common reproductive-endocrine disorder affecting between 5 and 18% of women worldwide. An elevated frequency of pulsatile luteinizing hormone (LH) secretion and higher serum levels of anti-Müllerian hormone (AMH) are frequently observed in women with PCOS. The origin of these abnormalities is, however, not well understood. Methods We studied brain structure and function in women with and without PCOS using proton magnetic resonance spectroscopy (MRS) and diffusion tensor imaging combined with fiber tractography. Then, using a mouse model of PCOS, we investigated by electron microscopy whether AMH played a role on the regulation of hypothalamic structural plasticity. Findings Increased AMH serum levels are associated with increased hypothalamic activity/axonal-glial signalling in PCOS patients. Furthermore, we demonstrate that AMH promotes profound micro-structural changes in the murine hypothalamic median eminence (ME), creating a permissive environment for GnRH secretion. These include the retraction of the processes of specialized AMH-sensitive ependymo-glial cells called tanycytes, allowing more GnRH neuron terminals to approach ME blood capillaries both during the run-up to ovulation and in a mouse model of PCOS. Interpretation We uncovered a central function for AMH in the regulation of fertility by remodeling GnRH terminals and their tanycytic sheaths, and provided insights into the pivotal role of the brain in the establishment and maintenance of neuroendocrine dysfunction in PCOS.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Projet Européen :

Extra-gonadal roles of Anti-Müllerian Hormone in the aetiology of polycystic ovary syndrome: the domino effect to reproductive neuroendocrine dysfunctions

Collections :

• Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277
• Lille Neurosciences & Cognition (LilNCog) - U 1172
• Plateformes Lilloises en Biologie et Santé (PLBS) - UAR 2014 - US 41

Date de dépôt :

2023-12-21T06:39:25Z
2024-02-23T09:26:34Z
2024-02-23T10:54:44Z