Title :

AllergoOncology: Opposite outcomes of immune tolerance in allergy and cancer

Author(s) :

Jensen‐jarolim, E [Auteur]
Bax, Heather [Auteur]
Bianchini, R. [Auteur]
Crescioli, Silvia [Auteur]
Daniels-Wells, T. [Auteur]
Dombrowicz, David [Auteur]
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U 1011 [RNMCD]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Fiebiger, E. [Auteur]
Gould, H [Auteur]
Irshad, Sheeba [Auteur]
Janda, J. [Auteur]
Josephs, Debra [Auteur]
Levi-Schaffer, F. [Auteur]
Pellizzari, Giulia [Auteur]
Penichet, Manuel [Auteur]
Redegeld, F. [Auteur]
Roth-Walter, F. [Auteur]
Singer, J. [Auteur]
Untersmayr, E. [Auteur]
Vangelista, L. [Auteur]
Karagiannis, Sophia [Auteur]

Journal title :

Allergy

Pages :

328-340

Publisher :

Wiley

Publication date :

2017-10-05

ISSN :

0105-4538

English keyword(s) :

Allergy allergooncology cancer oncoimmunology tolerance
Allergy
allergooncology
cancer
oncoimmunology
tolerance

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Abstract While desired for the cure of allergy, regulatory immune cell subsets and nonclassical Th2‐biased inflammatory mediators in the tumour microenvironment can contribute to immune suppression and escape of tumours ...
Show more >Abstract While desired for the cure of allergy, regulatory immune cell subsets and nonclassical Th2‐biased inflammatory mediators in the tumour microenvironment can contribute to immune suppression and escape of tumours from immunological detection and clearance. A key aim in the cancer field is therefore to design interventions that can break immunological tolerance and halt cancer progression, whereas on the contrary allergen immunotherapy exactly aims to induce tolerance. In this position paper, we review insights on immune tolerance derived from allergy and from cancer inflammation, focusing on what is known about the roles of key immune cells and mediators. We propose that research in the field of AllergoOncology that aims to delineate these immunological mechanisms with juxtaposed clinical consequences in allergy and cancer may point to novel avenues for therapeutic interventions that stand to benefit both disciplines.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Récepteurs nucléaires, Maladies Cardiovasculaires et Diabète (RNMCD) - U1011

Source :

Harvested from HAL