Title :

Ffar2 expression regulates leukaemic cell growth in vivo

Author(s) :

Bindels, Laure [Auteur]
Porporato, Paolo [Auteur]
Ducastel, Sarah [Auteur]
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U 1011 [RNMCD]
Sboarina, Martina [Auteur]
Neyrinck, Audrey [Auteur]
Dewulf, Evelyne [Auteur]
Feron, Olivier [Auteur]
Lestavel, Sophie [Auteur]
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U 1011 [RNMCD]
Cani, Patrice [Auteur]
Staels, Bart [Auteur]
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U 1011 [RNMCD]
Sonveaux, Pierre [Auteur]
Delzenne, Nathalie [Auteur]

Journal title :

British Journal of Cancer

Pages :

1336-1340

Publisher :

Cancer Research UK

Publication date :

2017-09-05

ISSN :

0007-0920

English keyword(s) :

cell proliferation CMTB free fatty acid receptor FFA2 GPR43 leukaemic cells propionate short-chain fatty acids
cell proliferation
CMTB
free fatty acid receptor
FFA2
GPR43
leukaemic cells
propionate
short-chain fatty acids

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Background: Activation of free fatty acid receptor 2 (FFAR2) by microbiota-derived metabolites (e.g., propionate) reduces leukaemic cell proliferation in vitro. This study aims to test whether Ffar2 expression per se also ...
Show more >Background: Activation of free fatty acid receptor 2 (FFAR2) by microbiota-derived metabolites (e.g., propionate) reduces leukaemic cell proliferation in vitro. This study aims to test whether Ffar2 expression per se also influences leukaemia cell growth in vivo. Methods: Bcr-Abl-expressing BaF cells were used as a leukaemia model and the role of Ffar2 was evaluated in Balb/c mice after lentiviral shRNA transduction. Results: Our data formally establish that reduced leukaemic cell proliferation is associated with increased Ffar2 expression in vivo and in vitro. Going beyond association, we point out that decreasing Ffar2 expression fosters cancer cell growth in vitro and in vivo. Conclusions: Our data demonstrate the role of Ffar2 in the control of leukaemic cell proliferation in vivo and indicate that a modulation of Ffar2 expression through nutritional tools or pharmacological agents may constitute an attractive therapeutic approach to tackle leukaemia progression in humans.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Récepteurs nucléaires, Maladies Cardiovasculaires et Diabète (RNMCD) - U1011

Source :

Harvested from HAL