Title :

Cognitive Outcome After Islet Transplantation

Author(s) :

Mailliez, Aurélie [Auteur]
Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE]
Ternynck, Camille [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Jannin, Arnaud [Auteur]
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Lemaître, Madleen [Auteur]
Chevalier, Benjamin [Auteur]
Le Mapihan, Kristell [Auteur]
Defrance, Frédérique [Auteur]
Mackowiak, Marie-Anne [Auteur]
Rollin, Adeline [Auteur]
Mehdi, Maanaoui [Auteur]
Chetboun, Mikael [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Pattou, François [Auteur]
Pasquier, Florence [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Vantyghem, Marie-Christine [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]

Journal title :

Transplantation Direct

Pages :

e1493

Publisher :

Wolters Kluwer

Publication date :

2023-05-26

ISSN :

2373-8731

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Background. Severe or repeated hypoglycemia events may favor memory complaints in type 1 diabetes (T1D). Pancreatic islet transplantation (IT) is an alternative option to exogenous insulin therapy in case of labile T1D, ...
Show more >Background. Severe or repeated hypoglycemia events may favor memory complaints in type 1 diabetes (T1D). Pancreatic islet transplantation (IT) is an alternative option to exogenous insulin therapy in case of labile T1D, implying a maintenance immunosuppression regimen based on sirolimus or mycophenolate, associated with tacrolimus, that may also have neurological toxicity. The objective of this study was to compare a cognitive rating scale Mini-Mental State Examination (MMSE) between T1D patients with or without IT and to identify parameters influencing MMSE. Methods. This retrospective cross-sectional study compared MMSE and cognitive function tests between islet-transplanted T1D patients and nontransplanted T1D controls who were transplant candidates. Patients were excluded if they refused. Results. Forty-three T1D patients were included: 9 T1D patients before IT and 34 islet-transplanted patients (14 treated with mycophenolate and 20 treated with sirolimus). Neither MMSE score ( P = 0.70) nor higher cognitive function differed between islet versus non–islet-transplanted patients, whatever the type of immunosuppression. In the whole population (N = 43), MMSE score was negatively correlated to glycated hemoglobin ( r = –0.30; P = 0.048) and the time spent in hypoglycemia on the continuous glucose monitoring ( r = –0.32; P = 0.041). MMSE score was not correlated to fasting C-peptide level, time spent in hyperglycemia, average blood glucose, time under immunosuppression, duration of diabetes, or beta-score (success score of IT). Conclusions. This first study evaluating cognitive disorders in islet-transplanted T1D patients argues for the importance of glucose balance on cognitive function rather than of immunosuppressive treatment, with a favorable effect of glucose balance improvement on MMSE score after IT.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167

Source :

Harvested from HAL