Title :

Feeding our immune system: impact on metabolism.

Author(s) :

Wolowczuk, Isabelle [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Verwaerde, Claudie [Auteur]
Médecine cellulaire et moléculaire [MCM]
Viltart, Odile [Auteur]
Institut Pasteur de Lille
Université de Lille, Sciences et Technologies
Delanoye, Anne [Auteur]
Médecine cellulaire et moléculaire [MCM]
Delacre, Myriam [Auteur]
Institut Pasteur de Lille
Pot, Bruno [Auteur]
Institut Pasteur de Lille
Grangette, Corinne [Auteur]
Institut Pasteur de Lille

Journal title :

Journal of Immunology Research

Abbreviated title :

J Immunol Res

Volume number :

2008

Pages :

639803

Publisher :

Hindawi Publishing Corporation

Publication date :

2008-02-25

ISSN :

2314-8861

English keyword(s) :

Animals
Dogs
Energy Metabolism
Fatty Acids
Glucose
Humans
Immune System
Immunity, Active
Immunity, Innate
Immunity, Mucosal
Mice
Nutritional Status
Rats
Toll-Like Receptors

HAL domain(s) :

Sciences cognitives

English abstract : [en]

Endogenous intestinal microflora and environmental factors, such as diet, play a central role in immune homeostasis and reactivity. In addition, microflora and diet both influence body weight and insulin-resistance, notably ...
Show more >Endogenous intestinal microflora and environmental factors, such as diet, play a central role in immune homeostasis and reactivity. In addition, microflora and diet both influence body weight and insulin-resistance, notably through an action on adipose cells. Moreover, it is known since a long time that any disturbance in metabolism, like obesity, is associated with immune alteration, for example, inflammation. The purpose of this review is to provide an update on how nutrients-derived factors (mostly focusing on fatty acids and glucose) impact the innate and acquired immune systems, including the gut immune system and its associated bacterial flora. We will try to show the reader how the highly energy-demanding immune cells use glucose as a main source of fuel in a way similar to that of insulin-responsive adipose tissue and how Toll-like receptors (TLRs) of the innate immune system, which are found on immune cells, intestinal cells, and adipocytes, are presently viewed as essential actors in the complex balance ensuring bodily immune and metabolic health. Understanding more about these links will surely help to study and understand in a more fundamental way the common observation that eating healthy will keep you and your immune system healthy.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CNRS
CHU Lille

Collections :

• Autres travaux scientifiques

Submission date :

2024-01-10T15:19:39Z
2024-02-07T08:48:23Z