Title :

Impact of Preformed Donor-Specific Anti-HLA-Cw and Anti-HLA-DP Antibodies on Acute Antibody-Mediated Rejection in Kidney Transplantation.

Author(s) :

Laboux, Timothee [Auteur]
Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE]
Lenain, Remi [Auteur]
MethodS in Patients-centered outcomes and HEalth ResEarch [SPHERE]
Visentin, Jonathan [Auteur]
Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
Flahaut, Gauthier [Auteur]
Université de Picardie Jules Verne [UPJV]
Chamley, Paul [Auteur]
Provôt, François [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Top, Isabelle [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Kerleau, Clarisse [Auteur]
Institut de transplantation urologie-néphrologie [ITUN]
Centre de Recherche en Transplantation et Immunologie [U1064 Inserm - CRTI]
Labalette, Myriam [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Choukroun, Gabriel [Auteur]
Mécanismes physiopathologiques et conséquences des calcifications cardiovasculaires - UR UPJV 7517 [MP3CV]
Couzi, Lionel [Auteur]
Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
Blancho, Gilles [Auteur]
Institut de transplantation urologie-néphrologie [ITUN]
Centre de Recherche en Transplantation et Immunologie [U1064 Inserm - CRTI]
Hazzan, Marc [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Maanaoui, Mehdi [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]

Journal title :

Transplant International

Abbreviated title :

Transpl Int

Volume number :

36

Pages :

11416

Publication date :

2023-12-12

ISSN :

1432-2277

English keyword(s) :

donor-specific antibodies
kidney transplant
acute antibody-mediated rejection
HLA-Cw
HLA-DP

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Given the risk of rejection, the presence of preformed donor specific antibodies (DSA) contraindicates transplantation in most allocation systems. However, HLA-Cw and -DP DSA escape this censorship. We performed a multicentric ...
Show more >Given the risk of rejection, the presence of preformed donor specific antibodies (DSA) contraindicates transplantation in most allocation systems. However, HLA-Cw and -DP DSA escape this censorship. We performed a multicentric observational study, in which the objective was to determinate risk factors of acute antibody-mediated rejection (aABMR) in recipients transplanted with preformed isolated Cw- or DP-DSA. Between 2010 and 2019, 183 patients were transplanted with a preformed isolated Cw- or DP-DSA (92 Cw-DSA; 91 DP-DSA). At 2 years, the incidence of aABMR was 12% in the Cw-DSA group, versus 28% in the DP-DSA group. Using multivariable Cox regression model, the presence of a preformed DP-DSA was associated with an increased risk of aABMR (HR = 2.32 [1.21–4.45 (p = 0.001)]) compared with Cw-DSA. We also observed a significant association between the DSA’s MFI on the day of transplant and the risk of aABMR (HR = 1.09 [1.08–1.18], p = 0.032), whatever the DSA was. Interaction term analysis found an increased risk of aABMR in the DP-DSA group compared with Cw-DSA, but only for MFI below 3,000. These results may plead for taking these antibodies into account in the allocation algorithms, in the same way as other DSA.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
• Recherche translationnelle sur le diabète (RTD) - U1190

Submission date :

2024-01-11T22:02:51Z
2024-01-31T15:04:46Z