Title :

Heart and systemic sclerosis-findings from a national cohort study.

Author(s) :

Guédon, Alexis F. [Auteur]
Institut Pierre Louis d'Epidémiologie et de Santé Publique [iPLESP]
Sorbonne Université [SU]
Carrat, Fabrice [Auteur]
Institut Pierre Louis d'Epidémiologie et de Santé Publique [iPLESP]
CHU Saint-Antoine [AP-HP]
Mouthon, Luc [Auteur]
Centre de référence des maladies auto-immunes systémiques rares d'Île-de-France / National Reference Center for Rare Systemic Autoimmune Diseases
Launay, David [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Chaigne, Benjamin [Auteur]
Centre de référence des maladies auto-immunes systémiques rares d'Île-de-France / National Reference Center for Rare Systemic Autoimmune Diseases
Pugnet, Grégory [Auteur]
Centre d'investigation clinique de Toulouse [CIC 1436]
Lega, Jean-Christophe [Auteur]
Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 [LBBE]
Hot, Arnaud [Auteur]
Hôpital Edouard Herriot [CHU - HCL]
Cottin, Vincent [Auteur]
Hospices Civils de Lyon [HCL]
Agard, Christian [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Allanore, Yannick [Auteur]
Institut Cochin [IC UM3 (UMR 8104 / U1016)]
Fauchais, Anne-Laure [Auteur]
CHU Limoges
Jego, Patrick [Auteur]
Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
Dhote, Robin [Auteur]
Hôpital Avicenne [AP-HP]
Papo, Thomas [Auteur]
Assistance publique - Hôpitaux de Paris (AP-HP) [AP-HP]
Chatelus, Emmanuel [Auteur]
Centre Hospitalier Universitaire [Strasbourg] [CHU Strasbourg]
Bonnotte, Bernard [Auteur]
Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand [CHU Dijon]
Khan, Jean-Emmanuel [Auteur]
Service de médecine interne [CHU Ambroise Paré]
Diot, Elisabeth [Auteur]
Centre Hospitalier Régional Universitaire de Tours [CHRU Tours]
Bienvenu, Boris [Auteur]
CHU Caen
Magy-Bertrand, Nadine [Auteur]
Centre Hospitalier Régional Universitaire de Besançon [CHRU Besançon]
Queyrel, Viviane [Auteur]
Centre Hospitalier Universitaire de Nice [CHU Nice]
Le Quellec, Alain [Auteur]
Hôpital Saint Eloi [CHU Montpellier]
Kieffer, Pierre [Auteur]
Centre Hospitalier Emile Muller [Mulhouse] [CH E.Muller Mulhouse]
Amoura, Zahir [Auteur]
Assistance publique - Hôpitaux de Paris (AP-HP) [AP-HP]
Harlé, Jean-Robert [Auteur]
Assistance Publique - Hôpitaux de Marseille [APHM]
Gaultier, Jean Baptiste [Auteur]
Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] [CHU ST-E]
Balquet, Marie-Hélène [Auteur]
Centre Hospitalier de Lens
Wahl, Denis [Auteur]
Centre Hospitalier Régional Universitaire de Nancy [CHRU Nancy]
Lidove, Olivier [Auteur]
Groupe Hospitalier Diaconesses Croix Saint-Simon
Fain, Olivier [Auteur]
Sorbonne Université [SU]
Mékinian, Arsène [Auteur]
Sorbonne Université [SU]
Hachulla, Eric [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Rivière, Sebastien [Auteur]
Sorbonne Université [SU]

Journal title :

Rheumatology

Abbreviated title :

Rheumatology (Oxford)

Publication date :

2023-11-10

ISSN :

1462-0332

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Objectives Heart involvement is one of the leading causes of death in SSc. The prevalence of SSc-related cardiac involvement is poorly known. Our objective was to investigate the prevalence and prognosis burden of different ...
Show more >Objectives Heart involvement is one of the leading causes of death in SSc. The prevalence of SSc-related cardiac involvement is poorly known. Our objective was to investigate the prevalence and prognosis burden of different heart diseases in a nationwide cohort of patients with SSc. Methods We used data from a multicentric prospective study using the French SSc national database. Focusing on SSc-related cardiac involvement, we aimed to determine its incidence and risk factors. Results Of the 3528 patients with SSc, 312 (10.9%) had SSc-related cardiac involvement at baseline. They tended to have a diffuse SSc subtype more frequently and to have more severe clinical features, and presented more cardiovascular risk factors. From the 1646 patients available for follow-up analysis, SSc-related cardiac involvement was associated with an increased risk of death. There was no significant difference in overall survival between SSc-related cardiac involvement, ischaemic heart disease or pulmonary arterial hypertension. Regarding survival analysis, 98 patients developed SSc-related cardiac involvement at 5 years (5-year event rate 11.15%). Regarding reduced left ventricular ejection fraction <50% and left ventricular diastolic dysfunction, the 5-year event rate was 2.49% and 5.84%, respectively. Pericarditis cumulative incidence at 5 years was 3%. Diffuse SSc subtype was a risk factor for SSc-related cardiac involvement and pericarditis. Female sex was associated with less left ventricular diastolic dysfunction incidence. Conclusions Our results describe the incidence and prognostic burden of SSc-related cardiac involvement at a large scale, with gender and diffuse SSc subtype as risk factors. Further analyses should assess the potential impact of treatment on these various cardiac outcomes.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-11T22:04:32Z
2024-03-06T10:35:33Z