Title :

Proteomic biomarkers for survival in systemic sclerosis-associated pulmonary hypertension.

Author(s) :

Mismetti, Valentine [Auteur]
Santé Ingénierie Biologie Saint-Etienne [SAINBIOSE]
Delavenne, Xavier [Auteur]
Santé Ingénierie Biologie Saint-Etienne [SAINBIOSE]
Montani, David [Auteur]
Hypertension pulmonaire : physiopathologie et innovation thérapeutique [HPPIT]
Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
Bezzeghoud, Souad [Auteur]
Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] [CHU ST-E]
Centre d'Investigation Clinique - Epidémiologie Clinique [CHU Saint-Etienne] [CIC-EC 1408]
Delezay, Olivier [Auteur]
Santé Ingénierie Biologie Saint-Etienne [SAINBIOSE]
Université Jean Monnet - Saint-Étienne [UJM]
Hodin, Sophie [Auteur]
Santé Ingénierie Biologie Saint-Etienne [SAINBIOSE]
Launay, David [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Marchand-Adam, Sylvain [Auteur]
Centre Hospitalier Régional Universitaire de Tours [CHRU Tours]
Nunes, Hilario [Auteur]
Hypoxie et Poumon : pneumopathologies fibrosantes, modulations ventilatoires et circulatoires [H&P - U1272 Inserm]
Hôpital Avicenne [AP-HP]
Ollier, Edouard [Auteur]
Santé Ingénierie Biologie Saint-Etienne [SAINBIOSE]
Reynaud-Gaubert, Martine [Auteur]
Hôpital Nord [CHU - APHM]
Pastre, Jean [Auteur]
Hôpital Européen Georges Pompidou [APHP] [HEGP]
Traclet, Julie [Auteur]
Centre national de référence des maladies pulmonaires rares [Lyon] [CRMPM]
Hôpital Louis Pradel [CHU - HCL]
Quetant, Sébastien [Auteur]
Centre Hospitalier Universitaire [CHU Grenoble] [CHUGA]
Zeghmar, Sabrina [Auteur]
Hôpital Louis Pradel [CHU - HCL]
Bertoletti, Laurent [Auteur]
Santé Ingénierie Biologie Saint-Etienne [SAINBIOSE]
Centre d'Investigation Clinique - Epidémiologie Clinique [CHU Saint-Etienne] [CIC-EC 1408]
Cottin, Vincent [Auteur]
Centre national de référence des maladies pulmonaires rares [Lyon] [CRMPM]
Infections Virales et Pathologie Comparée - UMR 754 [IVPC]
Hôpital Louis Pradel [CHU - HCL]
Université Claude Bernard Lyon 1 [UCBL]

Journal title :

Respiratory Research

Abbreviated title :

Respir Res

Volume number :

24

Pages :

273

Publication date :

2023-11-09

ISSN :

1465-993X

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Background Interstitial lung disease (ILD) and pulmonary hypertension (PH) represent the major causes of mortality in systemic sclerosis (SSc). Patients with systemic sclerosis and combined PH and ILD (SSc-PH-ILD) generally ...
Show more >Background Interstitial lung disease (ILD) and pulmonary hypertension (PH) represent the major causes of mortality in systemic sclerosis (SSc). Patients with systemic sclerosis and combined PH and ILD (SSc-PH-ILD) generally have a poor prognosis. Predictors of survival and of potential benefit of treatment are lacking in patients with SSc-PH-ILD. Objective To identify specific plasma protein expression patterns associated with survival in patients with SSc-PH-ILD. Materials and methods Post-hoc analysis of a prospective multicenter French study in patients with PH-ILD. An untargeted proteomic analysis using mass spectrometry was performed to identify plasma protein changes associated with long-term overall survival in patients with SSc-PH-ILD. Results Thirty two patients were included in the analysis, of whom 13 died during follow-up (median survival: 76.5 months). At baseline, survivors had less severe hemodynamic impairment [pulmonary vascular resistance of 4.4 Wood Units (IQR 3–5.2) vs. 6.2 Wood Units (IQR 4.2–10.7)] and higher carbon monoxide diffusing capacity [median 39% (IQR 35–44%) vs. 25% (IQR 22–30.5%)], than the 13 patients who died. Seven proteins, associated with haemostasis and fibrosis, were differentially expressed according to patients’ survival. In the survivor group, two proteins were increased (ADAMTS13, SERPIND1) and five were decreased (PTGDS, OLFM1, C7, IGFBP7, FBN1) compared to the non-survivor groups. Conclusion The prognosis of SSc-PH-ILD patients is poor. This proteomic approach found 7 plasma proteins (involved in haemostasis and fibrosis pathways) associated with survival. These potential biomarkers may be good candidates to prognostic enrichment.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-11T22:06:02Z
2024-03-08T10:56:06Z