Title :

Monocytes from Uninfected Neonates Born to <i>Trypanosoma cruzi</i>-Infected Mothers Display Upregulated Capacity to Produce TNF-α and to Control Infection in Association with Maternally Transferred Antibodies.

Author(s) :

Flores, Amilcar [Auteur]
Universidad Mayor de San Simón [Cochabamba, Bolivie] [UMSS]
Alonso-Vega, Cristina [Auteur]
Universidad Mayor de San Simón [Cochabamba, Bolivie] [UMSS]
Hermann, Emmanuel [Auteur]
Université libre de Bruxelles [ULB]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Torrico, Mary-Cruz [Auteur]
Universidad Mayor de San Simón [Cochabamba, Bolivie] [UMSS]
Montaño Villarroel, Nair Alaide [Auteur]
Universidad Mayor de San Simón [Cochabamba, Bolivie] [UMSS]
Torrico, Faustino [Auteur]
Universidad Mayor de San Simón [Cochabamba, Bolivie] [UMSS]
Carlier, Yves [Auteur]
Université libre de Bruxelles [ULB]
Tulane University
Truyens, Carine [Auteur]
Université libre de Bruxelles [ULB]

Journal title :

Pathogens

Abbreviated title :

Pathogens

Volume number :

12

Publication date :

2023-10-04

ISSN :

2076-0817

English keyword(s) :

congenital chagas disease
monocytes
Trypanosoma cruzi-specific antibodies

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Activated monocytes/macrophages that produce inflammatory cytokines and nitric oxide are crucial for controlling Trypanosoma cruzi infection. We previously showed that uninfected newborns from T. cruzi infected mothers ...
Show more >Activated monocytes/macrophages that produce inflammatory cytokines and nitric oxide are crucial for controlling Trypanosoma cruzi infection. We previously showed that uninfected newborns from T. cruzi infected mothers (M+B- newborns) were sensitized to produce higher levels of inflammatory cytokines than newborns from uninfected mothers (M-B- newborns), suggesting that their monocytes were more activated. Thus, we wondered whether these cells might help limit congenital infection. We investigated this possibility by studying the activation status of M+B- cord blood monocytes and their ability to control T. cruzi in vitro infection. We showed that M+B- monocytes have an upregulated capacity to produce the inflammatory cytokine TNF-α and a better ability to control T. cruzi infection than M-B- monocytes. Our study also showed that T. cruzi-specific Abs transferred from the mother play a dual role by favoring trypomastigote entry into M+B- monocytes and inhibiting intracellular amastigote multiplication. These results support the possibility that some M+B- fetuses may eliminate the parasite transmitted in utero from their mothers, thus being uninfected at birth.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-11T22:11:58Z
2024-03-04T15:27:22Z