Title :

The intersection between alcohol-related liver disease and nonalcoholic fatty liver disease.

Author(s) :

Díaz, Luis Antonio [Auteur]
Pontificia Universidad Católica de Chile [UC]
Arab, Juan Pablo [Auteur]
University of Western Ontario [UWO]
Pontificia Universidad Católica de Chile [UC]
Louvet, Alexandre [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Bataller, Ramón [Auteur]
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
Arrese, Marco [Auteur]
Pontificia Universidad Católica de Chile [UC]

Journal title :

Nature Reviews Gastroenterology & Hepatology

Abbreviated title :

Nat Rev Gastroenterol Hepatol

Publication date :

2023-08-17

ISSN :

1759-5053

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Nonalcoholic fatty liver disease (NAFLD) and alcohol-related liver disease (ALD) are the leading causes of chronic liver disease worldwide. NAFLD and ALD share pathophysiological, histological and genetic features and both ...
Show more >Nonalcoholic fatty liver disease (NAFLD) and alcohol-related liver disease (ALD) are the leading causes of chronic liver disease worldwide. NAFLD and ALD share pathophysiological, histological and genetic features and both alcohol and metabolic dysfunction coexist as aetiological factors in many patients with hepatic steatosis. A diagnosis of NAFLD requires the exclusion of significant alcohol consumption and other causes of liver disease. However, data suggest that significant alcohol consumption is often under-reported in patients classified as having NAFLD and that alcohol and metabolic factors interact to exacerbate the progression of liver disease. In this Review, we analyse existing data on the interaction between alcohol consumption and metabolic syndrome as well as the overlapping features and differences in the pathogenesis of ALD and NAFLD. We also discuss the clinical implications of the coexistence of alcohol consumption, of any degree, in patients with evidence of metabolic derangement as well as the use of alcohol biomarkers to detect alcohol intake. Finally, we summarize the evolving nomenclature of fatty liver disease and describe a recent proposal to classify patients at the intersection of NAFLD and ALD. We propose that, regardless of the presumed aetiology, patients with fatty liver disease should be evaluated for both metabolic syndrome and alcohol consumption to enable better prognostication and a personalized medicine approach.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-11T22:22:18Z
2024-03-04T09:16:01Z