Effective immuno-therapeutic treatment of Canine Leishmaniasis.

Ramos, Rafael Antonio Nascimento; Giannelli, Alessio; Fasquelle, Francois; Scuotto, Angelo; Betbeder, Didier

Type de document :

Article dans une revue scientifique: Article original

DOI :

10.1371/journal.pntd.0011360

PMID :

37216392

URL permanente :

http://hdl.handle.net/20.500.12210/100566

Titre :

Effective immuno-therapeutic treatment of Canine Leishmaniasis.

Auteur(s) :

Ramos, Rafael Antonio Nascimento [Auteur]
Federal University of Pernambuco [Recife]
Giannelli, Alessio [Auteur]
Fasquelle, Francois [Auteur]

Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Scuotto, Angelo [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Betbeder, Didier [Auteur]

Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Titre de la revue :

PLoS Neglected Tropical Diseases

Nom court de la revue :

PLoS Negl Trop Dis

Numéro :

Pagination :

e0011360

Date de publication :

2023-05-22

ISSN :

1935-2735

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Background Canine Leishmaniasis (CanL) caused by the L. infantum species is one of the biggest threats to the health of the South American canine population. Chemotherapeutics currently used for the treatment of CanL ...
Lire la suite >Background Canine Leishmaniasis (CanL) caused by the L. infantum species is one of the biggest threats to the health of the South American canine population. Chemotherapeutics currently used for the treatment of CanL fail to induce a total parasite clearance while inducing numerous side effects. As CanL is an immunomodulated disease, the use of immuno-treatments should strengthen the deficient immune response of infected dogs. In this study, we evaluated a nasally administered immunotherapy in dogs naturally infected with L. infantum (stage 2), with both visceral and cutaneous manifestations. Noteworthy, some of them were also infected by other parasites (E. canis, D. immitis, A. platys), what worsen their chance of survival. Methodology/Principal findings The treatment was based on 2 intranasal (IN.) administrations of a killed L. infantum parasite loaded into maltodextrin nanoparticles, which treatment was compared with the classical oral administration of Miltefosine (2 mg/kg) for 28 days, as well as a combination of these 2 treatments. The results showed that two IN administrations significantly reduced the serology, and were at least as efficient as the chemotherapy to reduce the skin and bone marrow parasite burden, as well as clinical scores, and that unlike Miltefosine treatments, this nasally administered nanoparticle vaccine was without side effects. Conclusions These results confirm the feasibility of a simple therapeutic immuno-treatment against L. infantum infected dogs, which is a promising tool for future developments.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
Inserm
CHU Lille

Collections :

Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Date de dépôt :

2024-01-11T22:37:16Z
2024-02-28T13:58:41Z

Numéro de version	Lien	Date de modification
2	20.500.12210/100566*	2024-02-28T13:52:37Z
1	20.500.12210/100566.1	2024-01-11T22:37:16Z

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