Title :

A Simple Prognostic System in Myelofibrosis Patients Undergoing Allogeneic Stem Cell Transplant: A CIBMTR/EBMT analysis.

Author(s) :

Tamari, Roni [Auteur]
Memorial Sloane Kettering Cancer Center [New York]
Mclornan, Donal P. [Auteur]
University College London Hospitals NHS Foundation Trust [London, UK] [UCLH]
Ahn, Kwang Woo [Auteur]
Medical College of Wisconsin [Milwaukee] [MCW]
Estrada-Merly, Noel [Auteur]
Medical College of Wisconsin [Milwaukee] [MCW]
Hernandez-Boluda, Juan Carlos [Auteur]
Universitat Politècnica de València = Universitad Politecnica de Valencia = Polytechnic University of Valencia [UPV]
Giralt, Sergio A. [Auteur]
Memorial Sloane Kettering Cancer Center [New York]
Palmer, Jeanne M. [Auteur]
Mayo Clinic
Gale, Robert Peter [Auteur]
Imperial College London
Defilipp, Zachariah [Auteur]
Massachusetts General Hospital [Boston]
Marks, David I. [Auteur]
University Hospitals Bristol
Van Der Poel, Marjolein W. M. [Auteur]
Maastricht University Medical Centre [MUMC]
Verdonck, Leo F. [Auteur]
Battiwalla, Minoo [Auteur]
Sarah Cannon Research Institute [Nashville, Tennessee]
Díaz, Miguel Angel [Auteur]
Hospital Infantil Universitario Niño Jesús [HIUNJ]
Gupta, Vikas [Auteur]
Princess Margaret Hospital
Ali, Haris [Auteur]
City of Hope Comprehensive Cancer Center [Duarte]
Litzow, Mark Robert [Auteur]
Mayo Clinic [Rochester]
Lazarus, Hillard M. [Auteur]
Cleveland State University
Gergis, Usama [Auteur]
Jefferson (Philadelphia University + Thomas Jefferson University)
Bashey, Asad [Auteur]
Emory University [Atlanta, GA]
Liesveld, Jane L. [Auteur]
University of Rochester Medical Center [URMC]
Hashmi, Shahrukh [Auteur]
Mayo Clinic [Rochester]
Pu, Jeffrey J. [Auteur]
Beitinjaneh, Amer [Auteur]
University of Miami
Bredeson, Christopher N. [Auteur]
The Ottawa Hospital
Rizzieri, David A. [Auteur]
Savani, Bipin N. [Auteur]
Vanderbilt University Medical Center [Nashville]
Abid, Muhammad Bilal [Auteur]
Medical College of Wisconsin [Milwaukee] [MCW]
Ganguly, Siddhartha [Auteur]
Houston Methodist Hospital [Houston, TX, USA]
Agrawal, Vaibhav [Auteur]
City of Hope Comprehensive Cancer Center [Duarte]
Bacher, Vera Ulrike [Auteur]
Universität Bern / University of Bern [UNIBE]
Wirk, Baldeep [Auteur]
Penn State Health Milton S. Hershey Medical Center
Jain, Tania [Auteur]
Johns Hopkins University [JHU]
Cutler, Corey S. [Auteur]
Dana-Farber Cancer Institute [Boston]
Aljurf, Mahmoud [Auteur]
King Faisal Specialist Hospital and Resarch Centre [Riyadh, Saudi Arabia] [KFSHRC]
Kindwall-Keller, Tamila [Auteur]
University of Virginia
Kharfan-Dabaja, Mohamed A. [Auteur]
Mayo Clinic [Jacksonville]
Hildebrandt, Gerhard C. [Auteur]
University of Kentucky [UK]
Pawarode, Attaphol [Auteur]
University of Michigan Medical School [Ann Arbor]
Solh, Melhem M. [Auteur]
Emory University [Atlanta, GA]
Yared, Jean A. [Auteur]
University of Maryland [Baltimore]
Grunwald, Michael R. [Auteur]
Nathan, Sunita [Auteur]
Rush University Medical Center [Chicago]
Nishihori, Taiga [Auteur]
H. Lee Moffitt Cancer Center and Research Institute
Seo, Sachiko [Auteur]
Dokkyo Medical University
Scott, Bart L. [Auteur]
Fred Hutchinson Cancer Research Center [Seattle] [FHCRC]
Nakamura, Ryotaro [Auteur]
City of Hope Comprehensive Cancer Center [Duarte]
Oran, Betul [Auteur]
The University of Texas M.D. Anderson Cancer Center [Houston]
Czerw, Tomasz [Auteur]
Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology [MCMCC]
Yakoub-Agha, Ibrahim [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Saber, Wael [Auteur]
Medical College of Wisconsin [Milwaukee] [MCW]

Journal title :

Blood Advances

Abbreviated title :

Blood Adv

Publication date :

2023-05-04

ISSN :

2473-9537

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

To develop a prognostic model for patients undergoing allogeneic hematopoietic cell transplantation (allo-HCT) for myelofibrosis (MF), we examined the data of 623 patients undergoing allo-HCT between 2000 and 2016 in the ...
Show more >To develop a prognostic model for patients undergoing allogeneic hematopoietic cell transplantation (allo-HCT) for myelofibrosis (MF), we examined the data of 623 patients undergoing allo-HCT between 2000 and 2016 in the United States (the Center for International Blood and Marrow Transplant Research [CIBMTR] cohort). A Cox multivariable model was used to identify factors prognostic of mortality. A weighted score using these factors was assigned to patients who received transplantation in Europe (the European Bone Marrow Transplant [EBMT] cohort; n = 623). Patient age >50 years (hazard ratio [HR], 1.39; 95% confidence interval [CI], 0.98-1.96), and HLA-matched unrelated donor (HR, 1.29; 95% CI, 0.98-1.7) were associated with an increased hazard of death and were assigned 1 point. Hemoglobin levels <100 g/L at time of transplantation (HR, 1.63; 95% CI, 1.2-2.19) and a mismatched unrelated donor (HR, 1.78; 95% CI, 1.25-2.52) were assigned 2 points. The 3-year overall survival (OS) in patients with a low (1-2 points), intermediate (3-4 points), and high score (5 points) were 69% (95% CI, 61-76), 51% (95% CI, 46-56.4), and 34% (95% CI, 21-49), respectively (P < .001). Increasing score was predictive of increased transplant-related mortality (TRM; P = .0017) but not of relapse (P = .12). The derived score was predictive of OS (P < .001) and TRM (P = .002) but not of relapse (P = .17) in the EBMT cohort as well. The proposed system was prognostic of survival in 2 large cohorts, CIBMTR and EBMT, and can easily be applied by clinicians consulting patients with MF about the transplantation outcomes.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-11T22:51:20Z
2024-03-25T14:11:40Z