Title :

Vaccination of squirrel monkeys (Saimiri spp.) with nanoparticle based-Toxoplasma gondii antigens: new hope for captive susceptible species.

Author(s) :

Ducournau, Céline [Auteur]
Infectiologie et Santé Publique [ISP]
Cantin, Pauline [Auteur]
Infectiologie et Santé Publique [ISP]
Alerte, Vanessa [Auteur]
Quintard, Benoît [Auteur]
Parc Zoologique et Botanique de Mulhouse
Popelin-Wedlarski, Florine [Auteur]
Wedlarski, Rudy [Auteur]
Ollivet-Courtois, Florence [Auteur]
Ferri-Pisani Maltot, Johanne [Auteur]
Herkt, Clément [Auteur]
Université de Lille
Fasquelle, Francois [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Sannier, Mylène [Auteur]
Berthet, Mélanie [Auteur]
Muséum de Besançon
Fretay, Vanessa [Auteur]
Aubert, Dominique [Auteur]
Epidémiosurveillance de protozooses à transmission alimentaire et vectorielle [ESCAPE]
Villena, Isabelle [Auteur]
SFR CAP Santé (Champagne-Ardenne Picardie Santé)
Betbeder, Didier [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Moiré, Nathalie [Auteur]
Infectiologie et Santé Publique [ISP]
Dimier-Poisson, Isabelle [Auteur]
Infectiologie et Santé Publique [ISP]

Journal title :

International Journal for Parasitology

Abbreviated title :

Int J Parasitol

Volume number :

53

Pages :

333-346

Publication date :

2023-04-01

ISSN :

1879-0135

English keyword(s) :

Fatal toxoplasmosis
Vaccination
Immune responses
Protein vaccine
Nanoparticles
Squirrel monkeys

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Squirrel monkeys (Saimiri spp.), new world primates from South America, are very susceptible to toxoplasmosis. Numerous outbreaks of fatal toxoplasmosis in zoos have been identified around the world, resulting in acute ...
Show more >Squirrel monkeys (Saimiri spp.), new world primates from South America, are very susceptible to toxoplasmosis. Numerous outbreaks of fatal toxoplasmosis in zoos have been identified around the world, resulting in acute respiratory distress and sudden death. To date, preventive hygiene measures or available treatments are not able to significantly reduce this mortality in zoos. Therefore, vaccination seems to be the best long-term solution to control acute toxoplasmosis. Recently, we developed a nasal vaccine composed of total extract of soluble proteins of Toxoplasma gondii associated with muco-adhesive maltodextrin-nanoparticles. The vaccine, which generated specific cellular immune responses, demonstrated efficacy against toxoplasmosis in murine and ovine experimental models. In collaboration with six French zoos, our vaccine was used as a last resort in 48 squirrel monkeys to prevent toxoplasmosis. The full protocol of vaccination includes two intranasal sprays followed by combined intranasal and s.c. administration. No local or systemic side-effects were observed irrespective of the route of administration. Blood samples were collected to study systemic humoral and cellular immune responses up to 1 year after the last vaccination. Vaccination induced a strong and lasting systemic cellular immune response mediated by specific IFN-γ secretion by peripheral blood mononuclear cells. Since the introduction of vaccination, no deaths of squirrel monkeys due to T. gondii has been observed for more than 4 years suggesting the promising usage of our vaccine. Moreover, to explain the high susceptibility of naive squirrel monkeys to toxoplasmosis, their innate immune sensors were investigated. It was observed that Toll-like and Nod-like receptors appear to be functional following T. gondii recognition suggesting that the extreme susceptibility to toxoplasmosis may not be linked to innate detection of the parasite.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-11T23:04:37Z
2024-02-06T08:41:12Z