Title :

New indices in predicting cardiometabolic risk and its relation to endothelial dysfunction in adolescents: The HELENA study.

Author(s) :

Nogueira, Maria D. A. [Auteur]

Braga, Ribanna A. M. [Auteur]

Manios, Yannis [Auteur]
Harokopio University of Athens
Androutsos, Odysseas [Auteur]
University of Thessaly [Volos] [UTH]
Molnár, Dénes [Auteur]
University of Pécs Medical School [UP MS]
Polito, Angela [Auteur]
Consiglio per la Ricerca in Agricoltura e l’analisi dell’economia agraria = Council for Agricultural Research and Economics [CREA]
Gómez-Martínez, Sonia [Auteur]
Beghin, Laurent [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Widhalm, Kurt [Auteur]
Medizinische Universität Wien = Medical University of Vienna
Bueno, Gloria [Auteur]
Universidad de Zaragoza = University of Zaragoza [Saragossa University] = Université de Saragosse
Castillo, Manuel J. [Auteur]
Universidad de Granada = University of Granada [UGR]
De Henauw, Stefaan [Auteur]
Universiteit Gent = Ghent University = Université de Gand [UGENT]
Moreno, Luis A. [Auteur]
Universidad de Zaragoza = University of Zaragoza [Saragossa University] = Université de Saragosse
Maia, Carla S.C. [Auteur]

Journal title :

Nutrition, Metabolism and Cardiovascular Diseases

Abbreviated title :

Nutr Metab Cardiovasc Dis

Publication date :

2023-03-26

ISSN :

1590-3729

English keyword(s) :

Blood pressure
Insulin resistance
Cardiovascular health
Endothelium
Adolescents

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Background and aims Blood pressure (BP) changes and insulin resistance (IR) are important cardiometabolic risk (CMR) factors; their early identification can contribute to the reduction of cardiovascular events in adulthood. ...
Show more >Background and aims Blood pressure (BP) changes and insulin resistance (IR) are important cardiometabolic risk (CMR) factors; their early identification can contribute to the reduction of cardiovascular events in adulthood. This necessitates the search for more accessible and easily applied indicators for their prediction. Therefore, this study aimed to evaluate the predictive power of the indices, TyG, TG/HDL-c, height-corrected lipid accumulation product (HLAP), and visceral adiposity index (VAI), in identifying the CMR obtained by high BP and IR and to verify their relationship with biomarkers of endothelial dysfunction (ED) in European adolescents. Methods and results The anthropometric data and blood biomarkers of 744 adolescents (343 boys and 401 girls) from the Healthy Lifestyle in Europe by Nutrition in Adolescence Cross-Sectional Study (HELENA-CSS), with a mean age of 14.67 (SD 1.15) years, were assessed. The adolescents were then classified according to the presence or absence of high BP and IR. The cut-off points of the indices evaluated for the identification of CMR were determined. The relationship between CMR diagnosed using these indices and ED biomarkers was tested. The HLAP and TG/HDL-c were fair predictors of CMR obtained by IR in male adolescents. These indices showed association with hsCRP in sVCAM-1 in boys, but it lost significance after adjusting for age and body mass index. Conclusion TG/HDL-c and HLAP indices showed a fair performance in predicting CMR, obtained by IR, in male adolescents. ED showed no association with the CMR identified by the indices.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-11T23:10:06Z
2024-03-25T13:12:40Z