Title :

Long-term outcome of liver transplantation for autoimmune hepatitis: a French nationwide study over 30 years.

Author(s) :

Chouik, Yasmina [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Chazouillères, Olivier [Auteur]
Centre de Recherche Saint-Antoine [UMRS893]
Francoz, Claire [Auteur]
Centre de recherche sur l'Inflammation [CRI (UMR_S_1149 / ERL_8252 / U1149)]
De Martin, Eleonora [Auteur]
Physiopathologie et traitement des maladies du foie
Guillaud, Olivier [Auteur]
Hôpital Edouard Herriot [CHU - HCL]
Abergel, Armand [Auteur]
CHU Estaing [Clermont-Ferrand]
Altieri, Mario [Auteur]
Barbier, Louise [Auteur]
Centre Hospitalier Régional Universitaire de Tours [CHRU Tours]
Besch, Camille [Auteur]
Conti, Filomena [Auteur]
Corpechot, Christophe [Auteur]
Centre de Recherche Saint-Antoine [CRSA]
Dharancy, Sebastien [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Durand, François [Auteur]
Centre de recherche sur l'Inflammation [CRI (UMR_S_1149 / ERL_8252 / U1149)]
Duvoux, Christophe [Auteur]
Gugenheim, Jean [Auteur]
Hardwigsen, Jean [Auteur]
Hilleret, Marie-Noëlle [Auteur]
Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) [IAB]
Houssel-Debry, Pauline [Auteur]
Kamar, Nassim [Auteur]
Maucort-Boulch, Delphine [Auteur]
Minello, Anne [Auteur]
Lipides - Nutrition - Cancer [Dijon - U1231] [LNC]
Neau-Cransac, Martine [Auteur]
Pageaux, Georges-Philippe [Auteur]
Radenne, Sylvie [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Roux, Olivier [Auteur]
Centre de recherche sur l'Inflammation [CRI (UMR_S_1149 / ERL_8252 / U1149)]
Saliba, Faouzi [Auteur]
Physiopathologie et traitement des maladies du foie
Serée, Olivier [Auteur]
Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers [ANTICIPE]
Samuel, Didier [Auteur]
Physiopathologie et traitement des maladies du foie
Vanlemmens, Claire [Auteur]
Woehl-Jaegle, Marie-Lorraine [Auteur]
Leroy, Vincent [Auteur]
Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) [IAB]
Duclos-Vallée, Jean-Charles [Auteur]
Physiopathologie et traitement des maladies du foie
Dumortier, Jerôme [Auteur]
Université Claude Bernard Lyon 1 [UCBL]

Journal title :

Liver International

Abbreviated title :

Liver Int

Volume number :

43

Pages :

1068-1079

Publication date :

2023-02-25

ISSN :

1478-3231

English keyword(s) :

biliary complication
chronic rejection
recurrence
sepsis
survival

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Background & Aims Autoimmune hepatitis (AIH) is a rare indication for liver transplantation (LT). The aims of this study were to evaluate long-term survival after LT for AIH and prognostic factors, especially the impact ...
Show more >Background & Aims Autoimmune hepatitis (AIH) is a rare indication for liver transplantation (LT). The aims of this study were to evaluate long-term survival after LT for AIH and prognostic factors, especially the impact of recurrent AIH (rAIH). Methods A multicentre retrospective nationwide study including all patients aged ≥16 transplanted for AIH in France was conducted. Early deaths and retransplantations (≤6 months) were excluded. Results The study population consisted of 301 patients transplanted from 1987 to 2018. Median age at LT was 43 years (IQR, 29.4–53.8). Median follow-up was 87.0 months (IQR, 43.5–168.0). Seventy-four patients (24.6%) developed rAIH. Graft survival was 91%, 79%, 65% at 1, 10 and 20 years respectively. Patient survival was 94%, 84% and 74% at 1, 10 and 20 years respectively. From multivariate Cox regression, factors significantly associated with poorer patient survival were patient age ≥58 years (HR = 2.9; 95% CI, 1.4–6.2; p = 0.005) and occurrence of an infectious episode within the first year after LT (HR = 2.5; 95% CI, 1.2–5.1; p = 0.018). Risk factors for impaired graft survival were: occurrence of rAIH (HR = 2.7; 95% CI, 1.5–5.0; p = 0.001), chronic rejection (HR = 2.9; 95% CI, 1.4–6.1; p = 0.005), biliary (HR = 2.0; 95% CI, 1.2–3.4; p = 0.009), vascular (HR = 1.8; 95% CI, 1.0–3.1; p = 0.044) and early septic (HR = 2.1; 95% CI, 1.2–3.5; p = 0.006) complications. Conclusion Our results confirm that survival after LT for AIH is excellent. Disease recurrence and chronic rejection reduce graft survival. The occurrence of an infectious complication during the first year post-LT identifies at-risk patients for graft loss and death.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-11T23:17:16Z
2024-01-30T08:28:16Z