Title :

French practical guidelines for the diagnosis and management of AA amyloidosis.

Author(s) :

Georgin-Lavialle, Sophie [Auteur]
CHU Tenon [AP-HP]
Savey, Léa [Auteur]
CHU Tenon [AP-HP]
Buob, D. [Auteur]
CHU Tenon [AP-HP]
Bastard, Jean-Philippe [Auteur]
Hôpital Henri Mondor
Fellahi, Soraya [Auteur]
CHU Tenon [AP-HP]
Karras, A. [Auteur]
Hôpital Européen Georges Pompidou [APHP] [HEGP]
Boffa, J. J. [Auteur]
CHU Tenon [AP-HP]
Grateau, Gilles [Auteur]
CHU Tenon [AP-HP]
Audard, Vincent [Auteur]
Bridoux, Franck [Auteur]
Damade, Richard [Auteur]
Deshayes, Samuel [Auteur]
Giurgea, Irina [Auteur]
Granel, Brigitte [Auteur]
Hachulla, Eric [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Hot, Arnaud [Auteur]
Jaccard, Arnaud [Auteur]
Knebelmann, Bertrand [Auteur]
Marciano, Sebastian [Auteur]
Pelcot, Françoise [Auteur]
Sarrabay, Guillaume [Auteur]
Boursier, Guilaine [Auteur]
Sellam, Jérémie [Auteur]
Terre, Alexandre [Auteur]
Bourguiba, Rim [Auteur]

Journal title :

La Revue de Médecine Interne

Abbreviated title :

Rev Med Interne

Volume number :

44

Pages :

62-71

Publication date :

2023-03-02

ISSN :

1768-3122

English keyword(s) :

AA amyloidosis
Inflammation
Kidney failure
Biopsy
Familial Mediterranean fever
Serum amyloid A protein (SAA)
Autoinflammatory diseases

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

AA amyloidosis is secondary to the deposit of excess insoluble Serum Amyloid A (SAA) protein fibrils. AA amyloidosis complicates chronic inflammatory diseases, especially chronic inflammatory rheumatisms such as rheumatoid ...
Show more >AA amyloidosis is secondary to the deposit of excess insoluble Serum Amyloid A (SAA) protein fibrils. AA amyloidosis complicates chronic inflammatory diseases, especially chronic inflammatory rheumatisms such as rheumatoid arthritis and spondyloarthritis; chronic infections such as tuberculosis, bronchectasia, chronic inflammatory bowel diseases such as Crohn's disease; and auto-inflammatory diseases including familial Mediterranean fever. This work consists of the French guidelines for the diagnosis workup and treatment of AA amyloidosis. We estimate in France between 500 and 700 cases in the whole French population, affecting both men and women. The most frequent organ impaired is kidney which usually manifests by oedemas of the lower extremities, proteinuria, and/or renal failure. Patients are usually tired and can display digestive features anf thyroid goiter. The diagnosis of AA amyloidosis is based on detection of amyloid deposits on a biopsy using Congo Red staining with a characteristic green birefringence in polarized light. Immunohistochemical analysis with an antibody directed against Serum Amyloid A protein is essential to confirm the diagnosis of AA amyloidosis. Peripheral inflammatory biomarkers can be measured such as C Reactive protein and SAA. We propose an algorithm to guide the etiological diagnosis of AA amyloidosis. The treatement relies on the etiologic treatment of the undelying chronic inflammatory disease to decrease and/or normalize Serum Amyloid A protein concentration in order to stabilize amyloidosis. In case of renal failure, dialysis or even a kidney transplant can be porposed. Nowadays, there is currently no specific treatment for AA amyloidosis deposits which constitutes a therapeutic challenge for the future.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-11T23:21:16Z
2024-03-19T15:09:36Z