Title :

The role of TAPSE/sPAP ratio in predicting pulmonary hypertension and mortality in the systemic sclerosis EUSTAR cohort.

Author(s) :

Colalillo, Amalia [Auteur]
Università degli Studi di Roma "La Sapienza" = Sapienza University [Rome] [UNIROMA]
Hoffmann-Vold, Anna-Maria [Auteur]
Oslo University Hospital [Oslo]
Pellicano, Chiara [Auteur]
Università degli Studi di Roma "La Sapienza" = Sapienza University [Rome] [UNIROMA]
Romaniello, Antonella [Auteur]
Università degli Studi di Roma "La Sapienza" = Sapienza University [Rome] [UNIROMA]
Gabrielli, Armando [Auteur]
Polytechnic University of Marche / Università Politecnica delle Marche [UNIVPM]
Hachulla, Eric [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Smith, Vanessa [Auteur]
Ghent University Hospital
Simeón-Aznar, Carmen-Pilar [Auteur]
Vall d'Hebron University Hospital [Barcelona]
Castellví, Ivan [Auteur]
Hospital de la Santa Creu i Sant Pau
Airò, Paolo [Auteur]
Civic Hospital of Brescia
Truchetet, Marie-Elise [Auteur]
Centre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
Siegert, Elise [Auteur]
Charité - UniversitätsMedizin = Berlin University Medicine
Distler, Oliver [Auteur]
University hospital of Zurich [Zurich]
Rosato, Edoardo [Auteur]
Università degli Studi di Roma "La Sapienza" = Sapienza University [Rome] [UNIROMA]

Journal title :

Autoimmunity Reviews

Abbreviated title :

Autoimmun Rev

Volume number :

22

Pages :

103290

Publication date :

2023-02-28

ISSN :

1873-0183

English keyword(s) :

TAPSE
sPAP ratio
Systemic sclerosis
Pulmonary hypertension
Right ventricle

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Objectives The study aim was to evaluate the predictive role of the echocardiography-derived tricuspid annular plane systolic excursion/systolic pulmonary artery pressure (TAPSE/sPAP) ratio for pulmonary hypertension ...
Show more >Objectives The study aim was to evaluate the predictive role of the echocardiography-derived tricuspid annular plane systolic excursion/systolic pulmonary artery pressure (TAPSE/sPAP) ratio for pulmonary hypertension (PH) diagnosis and mortality in the European Scleroderma Trials and Research (EUSTAR) cohort. Methods Eligible patients were systemic sclerosis (SSc) patients registered in the EUSTAR database with at least one visit recording TAPSE and sPAP data. Individual centres were required to provide TAPSE and sPAP data at 12 ± 3 months before right heart catheterization (RHC). Logistic regression analysis was applied to analyse the predictive ability of TAPSE/sPAP ratio for PH diagnosis. Cox regression analysis was performed to evaluate TAPSE/sPAP ratio as a predictive factor for all-cause mortality. Results 2555 SSc patients met the inclusion criteria for this study with 355 SSc patients having available RHC data at baseline. PH was confirmed by RHC in 195 SSc patients (54.9%). TAPSE/sPAP ratio < 0.55 mm/mmHg [OR 0.251 (95% CI 0.084–0.753), p < 0.05] and FVC/DLCO [OR 2.568 (95% CI 1.227–5.375), p < 0.05] were significantly associated with PH diagnosis. In logistic regression analysis with echocardiographic parameters at 12 ± 3 months before RHC, TAPSE/sPAP ratio < 0.55 mm/mmHg [OR 0.265 (95% CI 0.102–0.685), p < 0.01] and FVC/DLCO [OR 2.529 (95% CI 1.358–4.711), p < 0.01] were associated with PH diagnosis. In multivariate Cox regression analysis, TAPSE/sPAP ratio ≤ 0.32 mm/mmHg [HR 0.310 (0.164–0.585), p < 0.001] was the most significant predictive factor for death. Conclusions TAPSE/sPAP ratio < 0.55 mm/mmHg is a predictive risk factor for PH. TAPSE/sPAP ratio ≤ 0.32 mm/mmHg is a predictive risk marker for all-cause mortality.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-11T23:21:57Z
2024-03-04T10:46:08Z