Title :

Epidemiology, clinical presentation, and outcomes of 620 patients with eosinophilia in the intensive care unit.

Author(s) :

Gaillet, Antoine [Auteur]
Hôpital Foch [Suresnes]
AP-HP - Hôpital Bichat - Claude Bernard [Paris]
Bay, Pierre [Auteur]
Hôpital Henri Mondor
CHU Pitié-Salpêtrière [AP-HP]
Péju, Edwige [Auteur]
Hôpital Cochin [AP-HP]
Ait-Oufella, Hafid [Auteur]
CHU Saint-Antoine [AP-HP]
Azoulay, Elie [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Benchabane, Nacime [Auteur]
Hôpital Lapeyronie [CHU Montpellier]
Cerf, Charles [Auteur]
Hôpital Foch [Suresnes]
Cohen, Yves [Auteur]
Hôpital Avicenne [AP-HP]
De Prost, Nicolas [Auteur]
Hôpital Henri Mondor
Faguer, Stanislas [Auteur]
Centre Hospitalier Universitaire de Toulouse [CHU Toulouse]
Geri, Guillaume [Auteur]
Hôpital Ambroise Paré [AP-HP]
Grangé, Steven [Auteur]
CHU Rouen
Kahn, Jean-Emmannuel [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Hôpital Ambroise Paré [AP-HP]
Kreitmann, Louis [Auteur]
Hospices Civils de Lyon [HCL]
Larcher, Romaric [Auteur]
Centre Hospitalier Régional Universitaire [Montpellier] [CHRU Montpellier]
Lefevre, Guillaume [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Mabrouki, Asmaa [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Mekonsto Dessap, Armand [Auteur]
CHU Henri Mondor [Créteil]
Panel, Kewin [Auteur]
Hôpital Foch [Suresnes]
Pène, Frédéric [Auteur]
Hôpital Cochin [AP-HP]
Pineton De Chambrun, Marc [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Quenot, Jean-Pierre [Auteur]
Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand [CHU Dijon]
Tandjaoui-Lambiotte, Yacine [Auteur]
Hôpital Avicenne [AP-HP]
Timsit, Jean-François [Auteur]
AP-HP - Hôpital Bichat - Claude Bernard [Paris]
Vieillard-Baron, Antoine [Auteur]
Hôpital Ambroise Paré [AP-HP]
Dargent, Auguste [Auteur]
Hospices Civils de Lyon [HCL]
Herault, Antoine [Auteur]
CHU Rouen
Groh, Matthieu [Auteur]
Hôpital Foch [Suresnes]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]

Journal title :

Intensive Care Medicine

Abbreviated title :

Intensive Care Med

Publication date :

2023-02-02

ISSN :

1432-1238

English keyword(s) :

Diagnosis differential
Outcome assessment
Intensive care unit (ICU)
Hypereosinophilic syndrome
Eosinophilia

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Purpose Although eosinophil-induced manifestations can be life-threatening, studies focusing on the epidemiology and clinical manifestations of eosinophilia in the intensive care unit (ICU) are lacking. Methods A ...
Show more >Purpose Although eosinophil-induced manifestations can be life-threatening, studies focusing on the epidemiology and clinical manifestations of eosinophilia in the intensive care unit (ICU) are lacking. Methods A retrospective, national, multicenter (14 centers) cohort study over 6 years of adult patients who presented with eosinophilia ≥ 1 × 109/L on two blood samples performed from the day before admission to the last day of an ICU stay. Results 620 patients (0.9% of all ICU hospitalizations) were included: 40% with early eosinophilia (within the first 24 h of ICU admission, ICU-Eo1 group) and 56% with delayed (> 24 h after ICU admission, ICU-Eo2 group) eosinophilia. In ICU-Eo1, eosinophilia was mostly due to respiratory (14.9%) and hematological (25.8%) conditions, frequently symptomatic (58.1%, mainly respiratory and cardiovascular manifestations) requiring systemic corticosteroids in 32.2% of cases. In ICU-Eo2, eosinophil-related organ involvement was rare (25%), and eosinophilia was mostly drug-induced (46.8%). Survival rates at day 60 (D60) after ICU admission were 21.4% and 17.2% (p = 0.219) in ICU-Eo1 and ICU-Eo2 patients, respectively. For ICU-Eo1 patients, in multivariate analysis, risk factors for death at D60 were current immunosuppressant therapy at ICU admission, eosinophilia of onco-hematological origin and the use of vasopressors at ICU admission, whereas older age and the use of vasopressors or mechanical ventilation at the onset of eosinophilia were associated with a poorer prognosis for ICU-Eo2 patients. Conclusion Eosinophilia ≥ 1 × 109/L is not uncommon in the ICU. According to the timing of eosinophilia, two subsets of patients requiring different etiological workups and management can be distinguished.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-11T23:27:39Z
2024-03-08T14:03:10Z