Title :

On behalf of the SFGM-TC: prophylactic donor lymphocyte infusion in patients treated with allogeneic stem-cell transplantation for high-risk myelodysplastic syndrome and acute myeloid leukemia.

Author(s) :

Guisnel, Charles [Auteur]
Centre Hospitalier Universitaire de Nancy [CHU Nancy]
Schirmer, Luciane [Auteur]
Centre Hospitalier Régional Universitaire de Nancy [CHRU Nancy]
Morisset, Stéphane [Auteur]
Robin, Marie [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Labussière-Wallet, Hélène [Auteur]
Centre Hospitalier Lyon Sud [CHU - HCL] [CHLS]
Duléry, Rémy [Auteur]
CHU Saint-Antoine [AP-HP]
Ceballos, Patrice [Auteur]
Hôpital Saint Eloi [CHRU Montpellier]
Forcade, Edouard [Auteur]
Hôpital Haut-Lévêque [CHU Bordeaux]
Nguyen, Stéphanie [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Poiré, Xavier [Auteur]
Cliniques Universitaires Saint-Luc [Bruxelles]
Maertens, Johan [Auteur]
University Hospitals Leuven [Leuven]
Chantepie, Sylvain [Auteur]
Hôpital Côte de Nacre [CHU Caen]
Chevallier, Patrice [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Daguindau, Etienne [Auteur]
Centre Hospitalier Régional Universitaire de Besançon [CHRU Besançon]
Villate, Alban [Auteur]
Centre Hospitalier Régional Universitaire de Tours [CHRU Tours]
Charbonnier, Amandine [Auteur]
CHU Amiens-Picardie
Castilla-Llorente, Cristina [Auteur]
Institut Gustave Roussy [IGR]
Contentin, Nathalie [Auteur]
CHU Rouen
Huynh, Anne [Auteur]
Centre Hospitalier Universitaire de Toulouse [CHU Toulouse]
Yakoub-Agha, Ibrahim [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Bulabois, Claude Eric [Auteur]
Centre Hospitalier Universitaire [CHU Grenoble] [CHUGA]
Rubio, Marie-Thérèse [Auteur]
Centre Hospitalier Universitaire de Nancy [CHU Nancy]
D'aveni, Maud [Auteur]
Centre Hospitalier Universitaire de Nancy [CHU Nancy]

Journal title :

Acta Haematologica

Abbreviated title :

Acta Haematol

Publication date :

2023-01-07

ISSN :

1421-9662

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Introduction: Allogeneic hematopoietic stem-cell transplantation (allo-HSCT) remains the best curative option for high-risk myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Unfortunately, it is still ...
Show more >Introduction: Allogeneic hematopoietic stem-cell transplantation (allo-HSCT) remains the best curative option for high-risk myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Unfortunately, it is still associated with a significant risk of relapse due to mechanisms of escape from the control of alloreactive T cells. Repetitive adjuvant donor lymphocyte infusion (DLI), termed prophylactic DLI (proDLI), as an effective strategy in preventing relapse is still debated. Methods: We performed a retrospective multicenter study to evaluate the efficacy of proDLI in allografted AML and MDS. We identified 56 patients treated with proDLI (DLI planned in full chimeras without any sign of disease relapse) and matched them to 167 patients in control group, (DLI performed for mixed chimerism or positive minimal residual disease) based on similar age, initial disease, cytogenetic prognosis, and conditioning intensity. Results: In univariate analysis, the incidence of severe aGVHD at 100 days and incidence of all grades of chronic GVHD 1 year after allo-HSCT were similar in the two groups. We also observed a trend of higher 3-year RI (52.61% [95% confidence interval 25.99–79.23]) in the proDLI group versus the control group (29.31% [20.28–38.34], p = 0.067). However, 3-year overall survival (p = 0.892), progression-free survival (p = 0.239), and nonrelapse mortality (p = 0.343) were similar between the two groups. In multivariate analysis, the only factor influencing overall and progression-free survival was anti-thymocyte globulin administration during the conditioning regimen. Conclusion: The proDLI strategy had an acceptable toxicity profile but did not improve patient outcomes compared to the pre-emptive strategy.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-11T23:45:09Z
2024-03-11T09:27:23Z