Title :

Liver transplantation for autoimmune hepatitis: pre-transplant does not predict early post-transplant outcome.

Author(s) :

Chouik, Yasmina [Auteur]
Hospices Civils de Lyon [HCL]
Francoz, Claire [Auteur]
Centre de recherche sur l'Inflammation [CRI (UMR_S_1149 / ERL_8252 / U1149)]
De Martin, Eleonora [Auteur]
Physiopathologie et traitement des maladies du foie
Guillaud, Olivier [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Abergel, Armand [Auteur]
Institut Pascal [IP]
Altieri, Mario [Auteur]
Hôpital Côte de Nacre [CHU Caen]
Barbier, Louise [Auteur]
Hôpital Trousseau
Chazouillères, Olivier [Auteur]
Centre de Recherche Saint-Antoine [CRSA]
Conti, Filomena [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Corpechot, Christophe [Auteur]
Centre de Recherche Saint-Antoine [CRSA]
Dharancy, Sebastien [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Durand, François [Auteur]
Centre de recherche sur l'Inflammation [CRI (UMR_S_1149 / ERL_8252 / U1149)]
Duvoux, Christophe [Auteur]
Hôpital Henri Mondor
Gugenheim, Jean [Auteur]
Centre Hospitalier Universitaire de Nice [CHU Nice]
Hardwigsen, Jean [Auteur]
Hôpital de la Timone [CHU - APHM] [TIMONE]
Hilleret, Marie-Noëlle [Auteur]
Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) [IAB]
Houssel-Debry, Pauline [Auteur]
Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
Kamar, Nassim [Auteur]
Centre Hospitalier Universitaire de Toulouse [CHU Toulouse]
Minello, Anne [Auteur]
Epidémiologie et recherche clinique en oncologie digestive (CTM UMR 1231) [EPICAD]
Neau-Cransac, Martine [Auteur]
Hôpital Haut-Lévêque [CHU Bordeaux]
Pageaux, Georges-Philippe [Auteur]
CHU Montpellier = Montpellier University Hospital
Radenne, Sylvie [Auteur]
Hôpital de la Croix-Rousse [CHU - HCL]
Roux, Olivier [Auteur]
Centre de recherche sur l'Inflammation [CRI (UMR_S_1149 / ERL_8252 / U1149)]
Saliba, Faouzi [Auteur]
Centre Hépato-Biliaire [Hôpital Paul Brousse] [CHB]
Physiopathologie et traitement des maladies du foie
Samuel, Didier [Auteur]
Physiopathogénèse et Traitement des Maladies du Foie [HEPAREG]
Vanlemmens, Claire [Auteur]
Hôpital JeanMinjoz
Woehl-Jaegle, Marie-Lorraine [Auteur]
Hôpital de Hautepierre [Strasbourg]
Leroy, Vincent [Auteur]
Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) [IAB]
Duclos-Vallée, Jean-Charles [Auteur]
Physiopathologie et traitement des maladies du foie
Dumortier, Jerôme [Auteur]
Hospices Civils de Lyon [HCL]

Journal title :

Liver International

Abbreviated title :

Liver Int

Volume number :

43

Pages :

906-916

Publication date :

2022-12-30

ISSN :

1478-3231

English keyword(s) :

early infection
fulminant hepatitis
immunosuppression
sepsis
survival

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Background and Aims Autoimmune hepatitis (AIH) is a rare indication (<5%) for liver transplantation (LT). The aim of this study was to describe the early outcome after LT for AIH. Methods A multicenter retrospective ...
Show more >Background and Aims Autoimmune hepatitis (AIH) is a rare indication (<5%) for liver transplantation (LT). The aim of this study was to describe the early outcome after LT for AIH. Methods A multicenter retrospective nationwide study including all patients aged ≥16 transplanted for AIH in France was conducted. Occurrences of biliary and vascular complications, rejection, sepsis, retransplantation and death were collected during the first year after LT. Results A total of 344 patients (78.8% of women, 17.0% of (sub)fulminant hepatitis and 19.2% of chronic liver diseases transplanted in the context of acute-on-chronic liver failure [ACLF]) were included, with a median age at LT of 43.6 years. Acute rejection, sepsis, biliary and vascular complications occurred in respectively 23.5%, 44.2%, 25.3% and 17.4% of patients during the first year after LT. One-year graft and patient survivals were 84.3% and 88.0% respectively. The main cause of early death was sepsis. Pre-LT immunosuppression was not associated with an increased risk for early infections or surgical complications. Significant risk factors for septic events were LT in the context of (sub)fulminant hepatitis or ACLF, acute kidney injury at the time of LT (AKI) and occurrence of biliary complications after LT. AKI was the only independent factor associated with graft (HR = 2.5; 95% CI: 1.1–5.4; p = .02) and patient survivals (HR = 2.6; 95% CI: 1.0–6.5; p = .04). Conclusion Early prognosis is good after LT for AIH and is not impacted by pre-LT immunosuppression but by the presence of AKI at the time of LT.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-11T23:47:50Z
2024-03-27T10:03:31Z