Determination of four homogeneous subgroups ...
Document type :
Article dans une revue scientifique: Article original
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Permalink :
Title :
Determination of four homogeneous subgroups of patients with antiphospholipid syndrome: a cluster analysis based on 509 cases.
Author(s) :
Nguyen, Yann [Auteur]
Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques [CRESS (U1153 / UMR_A 1125)]
Yelnik, Cécile [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Centre National de Référence des Maladies Auto-Immunes Systémiques Rares du Nord et Nord-Ouest de France [CeRAINO]
Morel, Nathalie [Auteur]
Centre de référence des maladies auto-immunes systémiques rares d'Île-de-France / National Reference Center for Rare Systemic Autoimmune Diseases
Paule, Romain [Auteur]
Hôpital Foch [Suresnes]
Stammler, Romain [Auteur]
Service de médecine interne et centre de référence des maladies rares [CHU Cochin]
Plaçais, Léo [Auteur]
Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
Sacré, Karim [Auteur]
AP-HP - Hôpital Bichat - Claude Bernard [Paris]
Godeau, Bertrand [Auteur]
Hôpital Henri Mondor
Maillard, Hélène [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Launay, David [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Morell-Dubois, Sandrine [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Centre National de Référence des Maladies Auto-Immunes Systémiques Rares du Nord et Nord-Ouest de France [CeRAINO]
Dupré, Anastasia [Auteur]
Lefevre, Guillaume [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Devloo, Cécile [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Dufrost, Virginie [Auteur]
Défaillance Cardiovasculaire Aiguë et Chronique [DCAC]
Benhamou, Ygal [Auteur]
Endothélium, valvulopathies et insuffisance cardiaque [EnVI]
Levesque, Hervé [Auteur]
Université de Rouen Normandie [UNIROUEN]
Leroux, Gaëlle [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Piette, Jean-Charles [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Mouthon, Luc [Auteur]
Centre de référence des maladies auto-immunes systémiques rares d'Île-de-France / National Reference Center for Rare Systemic Autoimmune Diseases
Hachulla, Eric [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Lambert, Marc [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Le Guern, Véronique [Auteur]
Service de médecine interne et centre de référence des maladies rares [CHU Cochin]
Costedoat-Chalumeau, Nathalie [Auteur]
Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques [CRESS (U1153 / UMR_A 1125)]
Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques [CRESS (U1153 / UMR_A 1125)]
Yelnik, Cécile [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Centre National de Référence des Maladies Auto-Immunes Systémiques Rares du Nord et Nord-Ouest de France [CeRAINO]
Morel, Nathalie [Auteur]
Centre de référence des maladies auto-immunes systémiques rares d'Île-de-France / National Reference Center for Rare Systemic Autoimmune Diseases
Paule, Romain [Auteur]
Hôpital Foch [Suresnes]
Stammler, Romain [Auteur]
Service de médecine interne et centre de référence des maladies rares [CHU Cochin]
Plaçais, Léo [Auteur]
Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
Sacré, Karim [Auteur]
AP-HP - Hôpital Bichat - Claude Bernard [Paris]
Godeau, Bertrand [Auteur]
Hôpital Henri Mondor
Maillard, Hélène [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Launay, David [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Morell-Dubois, Sandrine [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Centre National de Référence des Maladies Auto-Immunes Systémiques Rares du Nord et Nord-Ouest de France [CeRAINO]
Dupré, Anastasia [Auteur]
Lefevre, Guillaume [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Devloo, Cécile [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Dufrost, Virginie [Auteur]
Défaillance Cardiovasculaire Aiguë et Chronique [DCAC]
Benhamou, Ygal [Auteur]
Endothélium, valvulopathies et insuffisance cardiaque [EnVI]
Levesque, Hervé [Auteur]
Université de Rouen Normandie [UNIROUEN]
Leroux, Gaëlle [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Piette, Jean-Charles [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Mouthon, Luc [Auteur]
Centre de référence des maladies auto-immunes systémiques rares d'Île-de-France / National Reference Center for Rare Systemic Autoimmune Diseases
Hachulla, Eric [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Lambert, Marc [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Le Guern, Véronique [Auteur]
Service de médecine interne et centre de référence des maladies rares [CHU Cochin]
Costedoat-Chalumeau, Nathalie [Auteur]
Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques [CRESS (U1153 / UMR_A 1125)]
Journal title :
Rheumatology
Abbreviated title :
Rheumatology (Oxford)
Volume number :
62
Pages :
2813–2819
Publication date :
2022-10-04
ISSN :
1462-0332
English keyword(s) :
APS
cluster analysis
SLE
cluster analysis
SLE
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Objective
APS is a heterogeneous disease with different phenotypes. Using an unsupervised hierarchical cluster analysis, we aimed to determine distinct homogeneous phenotypes among APS patients.
Methods
We performed ...
Show more >Objective APS is a heterogeneous disease with different phenotypes. Using an unsupervised hierarchical cluster analysis, we aimed to determine distinct homogeneous phenotypes among APS patients. Methods We performed an observational, retrospective study of APS patients enrolled in the French multicentre ‘APS and SLE’ registry who met the Sydney classification criteria. The clustering process involved an unsupervised multiple correspondence analysis followed by a hierarchical ascendant clustering analysis; it used 27 variables selected to cover a broad range of APS clinical and laboratory manifestations. Results These analyses included 509 patients, mainly women (77.8%). Mean (s.d.) age at APS diagnosis was 36.2 (14.6) years, and mean follow-up since diagnosis 10.3 (8.5) years. This hierarchical classification cluster analysis yielded four homogeneous groups of patients: cluster 1, mostly with venous thromboembolism without any associated autoimmune disease; cluster 2, older, lowest proportion of women, history of arterial events, and/or with migraines, arterial hypertension, diabetes mellitus, or dyslipidaemia; cluster 3, younger, highest proportion of women, associated SLE or other autoimmune diseases, and a history of venous thromboembolism or pregnancy morbidity; and cluster 4, mainly with a history of catastrophic antiphospholipid syndrome, aPL-associated nephropathy, and pregnancy morbidity, with frequent triple positivity and more deaths (16.7%). Conclusions Our study applied an unsupervised clustering method to distinguish four homogeneous APS patient subgroups that were predominantly venous; arterial; associated with SLE or another autoimmune disease; and arterial microthrombotic. Heterogeneous pathophysiological mechanisms may explain these findings.Show less >
Show more >Objective APS is a heterogeneous disease with different phenotypes. Using an unsupervised hierarchical cluster analysis, we aimed to determine distinct homogeneous phenotypes among APS patients. Methods We performed an observational, retrospective study of APS patients enrolled in the French multicentre ‘APS and SLE’ registry who met the Sydney classification criteria. The clustering process involved an unsupervised multiple correspondence analysis followed by a hierarchical ascendant clustering analysis; it used 27 variables selected to cover a broad range of APS clinical and laboratory manifestations. Results These analyses included 509 patients, mainly women (77.8%). Mean (s.d.) age at APS diagnosis was 36.2 (14.6) years, and mean follow-up since diagnosis 10.3 (8.5) years. This hierarchical classification cluster analysis yielded four homogeneous groups of patients: cluster 1, mostly with venous thromboembolism without any associated autoimmune disease; cluster 2, older, lowest proportion of women, history of arterial events, and/or with migraines, arterial hypertension, diabetes mellitus, or dyslipidaemia; cluster 3, younger, highest proportion of women, associated SLE or other autoimmune diseases, and a history of venous thromboembolism or pregnancy morbidity; and cluster 4, mainly with a history of catastrophic antiphospholipid syndrome, aPL-associated nephropathy, and pregnancy morbidity, with frequent triple positivity and more deaths (16.7%). Conclusions Our study applied an unsupervised clustering method to distinguish four homogeneous APS patient subgroups that were predominantly venous; arterial; associated with SLE or another autoimmune disease; and arterial microthrombotic. Heterogeneous pathophysiological mechanisms may explain these findings.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
Inserm
CHU Lille
Inserm
CHU Lille
Submission date :
2024-01-12T00:28:55Z
2024-03-11T10:13:44Z
2024-03-11T10:17:08Z
2024-03-11T10:13:44Z
2024-03-11T10:17:08Z