Title :

Cannabis use as a factor of lower corpulence in hepatitis C-infected patients: results from the ANRS CO22 Hepather cohort.

Author(s) :

Barré, Tangui [Auteur]
Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale [SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD]
Carrat, Fabrice [Auteur]
Institut Pierre Louis d'Epidémiologie et de Santé Publique [iPLESP]
Ramier, Clémence [Auteur]
Institut des sciences de la santé publique [Marseille] [ISSPAM]
Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale [SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD]
Fontaine, Hélène [Auteur]
Hôpital Cochin [AP-HP]
Di Beo, Vincent [Auteur]
Institut des sciences de la santé publique [Marseille] [ISSPAM]
Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale [SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD]
Bureau, Morgane [Auteur]
Institut des sciences de la santé publique [Marseille] [ISSPAM]
Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale [SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD]
Dorival, Céline [Auteur]
Institut Pierre Louis d'Epidémiologie et de Santé Publique [iPLESP]
Larrey, Dominique [Auteur]
Hôpital Saint Eloi [CHU Montpellier]
Delarocque-Astagneau, Elisabeth [Auteur]
Centre de recherche en épidémiologie et santé des populations [CESP]
Mathurin, Philippe [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Marcellin, Fabienne [Auteur]
Institut des sciences de la santé publique [Marseille] [ISSPAM]
Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale [SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD]
Petrov-Sanchez, Ventzislava [Auteur]
Agence Nationale de Recherches sur le Sida et les Hépatites Virales [ANRS]
Cagnot, Carole [Auteur]
Agence Nationale de Recherches sur le Sida et les Hépatites Virales [ANRS]
Carrieri, Patrizia [Auteur]
Institut des sciences de la santé publique [Marseille] [ISSPAM]
Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale [SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD]
Pol, Stanislas [Auteur]
Hôpital Cochin [AP-HP]
Protopopescu, Camelia [Auteur]
Institut des sciences de la santé publique [Marseille] [ISSPAM]
Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale [SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD]

Journal title :

Journal of Cannabis Research

Abbreviated title :

J Cannabis Res

Volume number :

4

Pages :

31

Publication date :

2022-06-13

ISSN :

2522-5782

English keyword(s) :

Cannabis
Marijuana
Hepatitis C
Chronic
Obesity
Body weight
Fibrosis
Behaviors
Delta 9-Tetrahydrocannabinol
Corpulence
Endocannabinoid system

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Background Patients with chronic hepatitis C virus (HCV) infection are at greater risk of developing metabolic disorders. Obesity is a major risk factor for these disorders, and therefore, managing body weight is crucial. ...
Show more >Background Patients with chronic hepatitis C virus (HCV) infection are at greater risk of developing metabolic disorders. Obesity is a major risk factor for these disorders, and therefore, managing body weight is crucial. Cannabis use, which is common in these patients, has been associated with lower corpulence in various populations. However, this relationship has not yet been studied in persons with chronic HCV infection. Methods Using baseline data from the French ANRS CO22 Hepather cohort, we used binary logistic and multinomial logistic regression models to test for an inverse relationship between cannabis use (former/current) and (i) central obesity (i.e., large waist circumference) and (ii) overweight and obesity (i.e., elevated body mass index (BMI)) in patients from the cohort who had chronic HCV infection. We also tested for relationships between cannabis use and both waist circumference and BMI as continuous variables, using linear regression models. Results Among the 6348 participants in the study population, 55% had central obesity, 13.7% had obesity according to their BMI, and 12.4% were current cannabis users. After multivariable adjustment, current cannabis use was associated with lower risk of central obesity (adjusted odds ratio, aOR [95% confidence interval, CI]: 0.45 [0.37–0.55]), BMI-based obesity (adjusted relative risk ratio (aRRR) [95% CI]: 0.27 [0.19–0.39]), and overweight (aRRR [95% CI]: 0.47 [0.38–0.59]). This was also true for former use, but to a lesser extent. Former and current cannabis use were inversely associated with waist circumference and BMI. Conclusions We found that former and, to a greater extent, current cannabis use were consistently associated with smaller waist circumference, lower BMI, and lower risks of overweight, obesity, and central obesity in patients with chronic HCV infection. Longitudinal studies are needed to confirm these relationships and to assess the effect of cannabis use on corpulence and liver outcomes after HCV cure.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-12T01:17:09Z
2024-03-14T14:40:50Z