Titre :

The gut environment regulates bacterial gene expression which modulates susceptibility to bacteriophage infection.

Auteur(s) :

Lourenço, Marta [Auteur]
Institut Pasteur [Paris] [IP]
Chaffringeon, Lorenzo [Auteur]
Bactériophage, bactérie, hôte - Bacteriophage, bacterium, host
Centre de Recherche Saint-Antoine [CRSA]
Lamy-Besnier, Quentin [Auteur]
Bactériophage, bactérie, hôte - Bacteriophage, bacterium, host
Titecat, Marie [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Pédron, Thierry [Auteur]
Institut Pasteur [Paris] [IP]
Sismeiro, Odile [Auteur]
Biomics (plateforme technologique)
Legendre, Rachel [Auteur]
Biomics (plateforme technologique)
Varet, Hugo [Auteur]
Pôle Biomics [C2RT]
Coppée, Jean-Yves [Auteur]
Biomics (plateforme technologique)
Bérard, Marion [Auteur]
De Sordi, Luisa [Auteur]
Centre de Recherche Saint-Antoine [CRSA]
Debarbieux, Laurent [Auteur]
Bactériophage, bactérie, hôte - Bacteriophage, bacterium, host

Titre de la revue :

Cell Host and Microbe

Nom court de la revue :

Cell Host Microbe

Numéro :

30

Pagination :

556-569.e5

Date de publication :

2022-04-17

ISSN :

1934-6069

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Abundance and diversity of bacteria and their viral predators, bacteriophages (phages), in the digestive tract are associated with human health. Particularly intriguing is the long-term coexistence of these two antagonistic ...
Lire la suite >Abundance and diversity of bacteria and their viral predators, bacteriophages (phages), in the digestive tract are associated with human health. Particularly intriguing is the long-term coexistence of these two antagonistic populations. We performed genome-wide RNA sequencing on a human enteroaggregative Escherichia coli isolate to identify genes differentially expressed between in vitro conditions and in murine intestines. We experimentally demonstrated that four of these differentially expressed genes modified the interactions between E. coli and three virulent phages by either increasing or decreasing its susceptibility/resistance pattern and also by interfering with biofilm formation. Therefore, the regulation of bacterial genes expression during the colonization of the digestive tract influences the coexistence of phages and bacteria, highlighting the intricacy of tripartite relationships between phages, bacteria, and the animal host in intestinal homeostasis.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Date de dépôt :

2024-01-12T01:44:19Z
2024-03-18T15:29:15Z