Predictors of anastomotic strictures following œsophageal atresia repair.

Aumar, Madeleine; Sfeir, Rony; Pierache, Adeline; Turck, Dominique; Gottrand, fréderic

Document type :

Article dans une revue scientifique: Article original

DOI :

10.1136/archdischild-2021-322577

PMID :

35217569

Permalink :

http://hdl.handle.net/20.500.12210/100888

Title :

Predictors of anastomotic strictures following œsophageal atresia repair.

Author(s) :

Aumar, Madeleine [Auteur]

Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Sfeir, Rony [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Pierache, Adeline [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Turck, Dominique [Auteur]

Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Gottrand, fréderic [Auteur]

Institute for Translational Research in Inflammation - U 1286 [INFINITE]

Journal title :

Archives of disease in childhood. Fetal and neonatal edition

Abbreviated title :

Arch Dis Child Fetal Neonatal Ed

Volume number :

107

Pages :

545-550

Publication date :

2022-02-27

ISSN :

1468-2052

English keyword(s) :

epidemiology
gastroenterology
neonatology
paediatrics

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Objectives To identify the risk factors for anastomotic, refractory and recurrent strictures and to establish whether anastomotic stricture is associated with antireflux surgery. Design This prospective national multicentre ...
Show more >Objectives To identify the risk factors for anastomotic, refractory and recurrent strictures and to establish whether anastomotic stricture is associated with antireflux surgery. Design This prospective national multicentre study included all infants born with oesophageal atresia (OA) over an 8-year period. Data on OA and complications were collected at birth and at 1 year old. Univariate and multivariate analyses were conducted. Results 1082 patients from 37 centres were included in the study. The prevalence of anastomotic stricture at 1 year old was 23.2%. Anastomosis under tension (defined by the surgeon at the time of repair) and delayed anastomosis (defined as anastomosis performed more than 15 days after birth, excluding delays due to prematurity or severe cardiac diseases) were found to be independent risk factors for anastomotic stricture (2.3 (1.42–3.74) and 4.02 (2.12–7.63), respectively). Patients with anastomotic stricture had a 2.3-fold higher rate of fundoplication compared with others (p=0.001). Anastomosis under tension and delayed anastomosis were found to be independent risk factors for recurrent stricture (1.92 (1.10–3.34) and 5.73 (2.71–12.14), respectively), while delayed anastomosis was the only risk factor for refractory stricture (8.30 (3.34–20.64)). There was a 2.39-fold (1.42–4.04) higher rate of fundoplication in the anastomotic stricture group than in the group without anastomotic stricture (p=0.001). Conclusions Patient-related anatomical factors leading to anastomosis under tension and delayed anastomosis increase the risk of anastomotic stricture.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

Submission date :

2024-01-12T02:13:04Z
2024-03-20T15:07:14Z

Version	Link	Modification date
2	20.500.12210/100888*	2024-03-20T15:04:23Z
1	20.500.12210/100888.1	2024-01-12T02:13:04Z

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