Title :

Nailfold capillaroscopy in SSc: innocent bystander or promising biomarker for novel severe organ involvement/progression?

Author(s) :

Vanhaecke, A. [Auteur]
Cutolo, M. [Auteur]
Distler, O. [Auteur]
Riccieri, V. [Auteur]
Allanore, Yannick [Auteur]
Hôpital Cochin [AP-HP]
Denton, C. P. [Auteur]
Hachulla, Eric [Auteur]
Centre National de Référence des Maladies Auto-Immunes Systémiques Rares du Nord et Nord-Ouest de France [CeRAINO]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Ingegnoli, F. [Auteur]
Deschepper, E. [Auteur]
Avouac, Jérôme [Auteur]
Hôpital Cochin [AP-HP]
Jordan, S. [Auteur]
Launay, David [Auteur]
Centre National de Référence des Maladies Auto-Immunes Systémiques Rares du Nord et Nord-Ouest de France [CeRAINO]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Melsens, K. [Auteur]
Pizzorni, C. [Auteur]
Sulli, A. [Auteur]
Vasile, M. [Auteur]
Herrick, A. L. [Auteur]
Smith, V. [Auteur]

Journal title :

Rheumatology

Abbreviated title :

Rheumatology (Oxford)

Volume number :

61

Pages :

4384–4396

Publication date :

2022-02-20

ISSN :

1462-0332

English keyword(s) :

SSc
microcirculation
nailfold videocapillaroscopy
organ involvement
disease progression
EULAR Study Group on Microcirculation in Rheumatic Diseases
EUSTAR

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Objectives Nailfold videocapillaroscopy (NVC) plays a well-established role in differentiating primary from secondary RP due to SSc. However, the association of NVC with novel severe organ involvement/progression in SSc ...
Show more >Objectives Nailfold videocapillaroscopy (NVC) plays a well-established role in differentiating primary from secondary RP due to SSc. However, the association of NVC with novel severe organ involvement/progression in SSc has never been evaluated in a multicentre, multinational study, which we now perform for the first time. Methods Follow-up data from 334 SSc patients [265 women; 18 limited SSc (lSSc)/203 lcSSc/113 dcSSc] registered between November 2008 and January 2016 by seven tertiary centres in the EUSTAR-database, were analysed. Novel severe organ involvement/progression was defined as new/progressive involvement of the peripheral vasculature, lungs, heart, skin, gastrointestinal tract, kidneys, musculoskeletal system, or death, at the 12- or 24-month follow-up. NVC images at enrolment were quantitatively and qualitatively evaluated according to the standardized definitions of the EULAR Study Group on Microcirculation in Rheumatic Diseases. Uni- and multivariable logistic regression modelling (ULR, MLR) was performed. Results Of the 334 included SSc patients, 257 (76.9%) developed novel overall severe organ involvement/progression. Following MLR, normal capillary density was associated with less-frequent novel overall severe organ involvement/progression [odds ratio (OR) = 0.77, P < 0.001] and novel peripheral vascular involvement (OR = 0.79, P = 0.043); microhaemorrhages were associated with less novel pulmonary hypertension (OR = 0.47, P = 0.029); and a ‘severe’ (active/late) NVC pattern was associated with novel overall severe organ involvement/progression (OR = 2.14, P = 0.002) and skin progression (OR = 1.70, P = 0.049). Conclusions Our results suggest that NVC may be a promising biomarker in SSc, certainly warranting further investigation. Despite the participation of tertiary centres, which follow their patients in a standardized way, we were underpowered to detect associations with infrequent severe organ involvement/progression.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-12T02:15:27Z
2024-03-21T08:55:42Z