Title :

Effective anti-SARS-CoV-2 immune response in patients with clonal mast cell disorders.

Author(s) :

Rossignol, Julien [Auteur]
Imagine - Institut des maladies génétiques (IHU) [Imagine - U1163]
Centre de référence des mastocytoses [CEREMAST]
Ouedrani, Amani [Auteur]
Institut Necker Enfants-Malades [INEM - UM 111 (UMR 8253 / U1151)]
Livideanu, Cristina Bulai [Auteur]
Centre de Référence des Mastocytoses de Toulouse [CEREMAST]
Barete, Stéphane [Auteur]
Centre de référence des mastocytoses [CEREMAST]
Terriou, Louis [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Launay, David [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Lemal, Richard [Auteur]
Centre d'Investigation Clinique [CHU Clermont-Ferrand] [CIC 1405]
Greco, Celine [Auteur]
Imagine - Institut des maladies génétiques (IHU) [Imagine - U1163]
Frenzel, Laurent [Auteur]
Imagine - Institut des maladies génétiques (IHU) [Imagine - U1163]
Meni, Cecile [Auteur]
Centre de référence des mastocytoses [CEREMAST]
Bodemere-Skandalis, Christine [Auteur]
Imagine - Institut des maladies génétiques (IHU) [Imagine - U1163]
Polivka, Laura [Auteur]
Imagine - Institut des maladies génétiques (IHU) [Imagine - U1163]
Collange, Anne-Florence [Auteur]
Hachichi, Hassiba [Auteur]
Centre de référence des mastocytoses [CEREMAST]
Bouzourine, Sonia [Auteur]
Centre de référence des mastocytoses [CEREMAST]
Messaoud, Djazira Nait [Auteur]
Negretto, Mathilde [Auteur]
Vendrame, Laurence [Auteur]
Jambou, Marguerite [Auteur]
Gousseff, Marie [Auteur]
Centre hospitalier Bretagne Atlantique (Morbihan) [CHBA]
Durupt, Stéphane [Auteur]
Hospices Civils de Lyon [HCL]
Lega, Jean-Christophe [Auteur]
Hospices Civils de Lyon [HCL]
Durand, Jean-Marc [Auteur]
Hôpital de la Timone [CHU - APHM] [TIMONE]
Gaudy, Caroline [Auteur]
Hôpital de la Timone [CHU - APHM] [TIMONE]
Damaj, Gandhi [Auteur]
Université de Caen Normandie [UNICAEN]
Gourin, Marie-Pierre [Auteur]
Service d'Hématologie clinique et thérapie cellulaire [CHU Limoges]
Hamidou, Mohamed [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Bouillet, Laurence [Auteur]
Centre de référence national des angiœdèmes [CREAK]
Le Mouel, Edwige [Auteur]
Maria, Alexandre [Auteur]
CHU Montpellier = Montpellier University Hospital
Zunic, Patricia [Auteur]
CHU Sud Saint Pierre [Ile de la Réunion]
Cabrera, Quentin [Auteur]
CHU Sud Saint Pierre [Ile de la Réunion]
Vincent, Denis [Auteur]
Centre Hospitalier Universitaire de Nîmes [CHU Nîmes]
Lavigne, Christian [Auteur]
Centre Hospitalier Universitaire d'Angers [CHU Angers]
Riviere, Etienne [Auteur]
Hôpital Haut-Lévêque [CHU Bordeaux]
Gourguechon, Clement [Auteur]
CHU Amiens-Picardie
Brignier, Anne [Auteur]
Imagine - Institut des maladies génétiques (IHU) [Imagine - U1163]
Lhermitte, Ludovic [Auteur]
Hôpital Necker - Enfants Malades [AP-HP]
Molina, Thierry Jo [Auteur]
Imagine - Institut des maladies génétiques (IHU) [Imagine - U1163]
Bruneau, Julie [Auteur]
Agopian, Julie [Auteur]
Centre d'Immunologie de Marseille - Luminy [CIML]
Institut Paoli-Calmettes [IPC]
Dubreuil, Patrice [Auteur]
Institut Paoli-Calmettes [IPC]
Ranta, Dana [Auteur]
Centre Hospitalier Régional Universitaire de Nancy [CHRU Nancy]
Mania, Alexandre [Auteur]
Centre d'Investigation Clinique [CHU Clermont-Ferrand] [CIC 1405]
Arock, Michel [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Staropoli, Isabelle [Auteur]
Virus et Immunité - Virus and immunity [CNRS-UMR3569]
Tournilhac, Olivier [Auteur]

Lortholary, Olivier [Auteur]
Schwartz, Olivier [Auteur]
Virus et Immunité - Virus and immunity [CNRS-UMR3569]
Chatenoud, Lucienne [Auteur]
Institut Necker Enfants-Malades [INEM - UM 111 (UMR 8253 / U1151)]
Hermine, Olivier [Auteur]

Journal title :

Journal of Allergy and Clinical Immunology: In Practice

Abbreviated title :

J Allergy Clin Immunol Pract

Volume number :

10

Publication date :

2022-01-26

ISSN :

2213-2201

English keyword(s) :

SARS-CoV-2
COVID-19
Mast cells
Mastocytosis
Clonal mast cell activation syndrome
Mast cell activation disorders
T cells
B cells

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Background Mast cells are key players in innate immunity and the TH2 adaptive immune response. The latter counterbalances the TH1 response, which is critical for antiviral immunity. Clonal mast cell activation disorders ...
Show more >Background Mast cells are key players in innate immunity and the TH2 adaptive immune response. The latter counterbalances the TH1 response, which is critical for antiviral immunity. Clonal mast cell activation disorders (cMCADs, such as mastocytosis and clonal mast cell activation syndrome) are characterized by abnormal mast cell accumulation and/or activation. No data on the antiviral immune response in patients with MCADs have been published. Objective To study a comprehensive range of outcomes in patients with cMCAD with PCR- or serologically confirmed coronavirus disease 2019 and to characterize the specific anti–severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immune response in this setting. Methods Clinical follow-up and outcome data were collected prospectively over a 12-month period by members of the French Centre de Référence des Mastocytoses rare disease network. Anti–SARS-CoV-2–specific T-cell activity was measured with an ELISA, and humoral responses were evaluated by assaying circulating levels of specific IgG, IgA, and neutralizing antibodies. Results Overall, 32 patients with cMCAD were evaluated. None required noninvasive or mechanical ventilation. Two patients were admitted to hospital for oxygen and steroid therapy. The SARS-CoV-2–specific immune response was characterized in 21 of the 32 patients. Most had high counts of circulating SARS-CoV-2–specific, IFN-γ–producing T cells and high titers of neutralizing antispike IgGs. The patients frequently showed spontaneous T-cell IFN-γ production in the absence of stimulation; this production was correlated with basal circulating tryptase levels (a marker of the mast cell burden). Conclusions Patients with cMCADs might not be at risk of severe coronavirus disease 2019, perhaps due to their spontaneous production of IFN-γ.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-12T02:25:13Z
2024-03-14T14:08:26Z