Severe alcoholic hepatitis as precipitant ...
Document type :
Article dans une revue scientifique: Article original
DOI :
PMID :
Permalink :
Title :
Severe alcoholic hepatitis as precipitant for organ failure and ACLF.
Translated title :
Schwere Alkoholhepatitis als präzipitierender Faktor für Organversagen und ACLF
Author(s) :
Trebicka, Jonel [Auteur]
Universitätsklinikum Frankfurt
Louvet, Alexandre [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Arroyo, Vincente [Auteur]
European Foundation for Study of Chronic Liver Failure [Barcelona] [EF CLIF]
Jalan, Rajiv [Auteur]
University College of London [London] [UCL]
Shah, Vijay H. [Auteur]
Mayo Clinic [Rochester]
Moreau, Richard [Auteur]
Centre de recherche biomédicale Bichat-Beaujon [CRB3]
Centre de recherche sur l'Inflammation [CRI (UMR_S_1149 / ERL_8252 / U1149)]
Universitätsklinikum Frankfurt
Louvet, Alexandre [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Arroyo, Vincente [Auteur]
European Foundation for Study of Chronic Liver Failure [Barcelona] [EF CLIF]
Jalan, Rajiv [Auteur]
University College of London [London] [UCL]
Shah, Vijay H. [Auteur]
Mayo Clinic [Rochester]
Moreau, Richard [Auteur]
Centre de recherche biomédicale Bichat-Beaujon [CRB3]
Centre de recherche sur l'Inflammation [CRI (UMR_S_1149 / ERL_8252 / U1149)]
Journal title :
Zeitschrift für Gastroenterologie
Abbreviated title :
Z Gastroenterol
Volume number :
60
Pages :
67-76
Publication date :
2022-01-20
ISSN :
1439-7803
English keyword(s) :
ASH
ACLF
systemic inflammation
liver transplantation
ACLF
systemic inflammation
liver transplantation
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Alcoholic hepatitis is the acute deterioration of alcoholic liver disease with rapid onset or worsening of jaundice, which in severe cases, may transition to acute-on-chronic liver failure with extremely high short-term ...
Show more >Alcoholic hepatitis is the acute deterioration of alcoholic liver disease with rapid onset or worsening of jaundice, which in severe cases, may transition to acute-on-chronic liver failure with extremely high short-term mortality, increasing with the number and severity of hepatic and extra-hepatic organ dysfunction. Diagnosis and treatment are insufficient and challenging, especially due to the complex, multi-factorial and as yet not fully understood pathogenesis. While current management is limited to steroids and best supportive care, debate is ongoing concerning liver transplantation for selected patients, and several novel approaches are under way with mixed results. These drawbacks in disease management together with increasing prevalence in Germany, and generally in Western countries, constitute an unmet need for the healthcare systems. This review tries to summarize the current status of these aspects and provides an overview for pathogenesis, management and potential future treatments.Show less >
Show more >Alcoholic hepatitis is the acute deterioration of alcoholic liver disease with rapid onset or worsening of jaundice, which in severe cases, may transition to acute-on-chronic liver failure with extremely high short-term mortality, increasing with the number and severity of hepatic and extra-hepatic organ dysfunction. Diagnosis and treatment are insufficient and challenging, especially due to the complex, multi-factorial and as yet not fully understood pathogenesis. While current management is limited to steroids and best supportive care, debate is ongoing concerning liver transplantation for selected patients, and several novel approaches are under way with mixed results. These drawbacks in disease management together with increasing prevalence in Germany, and generally in Western countries, constitute an unmet need for the healthcare systems. This review tries to summarize the current status of these aspects and provides an overview for pathogenesis, management and potential future treatments.Show less >
Language :
Allemand
Anglais
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
Inserm
CHU Lille
Inserm
CHU Lille
Submission date :
2024-01-12T02:28:23Z
2024-01-26T13:04:03Z
2024-01-26T13:04:03Z