Title :

Clinical phenotype and cytokine profile of adult IgA vasculitis with joint involvement.

Author(s) :

Delapierre, Alice [Auteur]
Université de Caen Normandie - UFR Santé [UNICAEN Santé]
Terrier, Benjamin [Auteur]
Institut Cochin [IC UM3 (UMR 8104 / U1016)]
Pillebout, Evangéline [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Baudart, Pauline [Auteur]
Université de Caen Normandie - UFR Santé [UNICAEN Santé]
Jourde-Chiche, Noémie [Auteur]
Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research [C2VN]
Lioger, Bertrand [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Martis, Nihal [Auteur]
Centre Hospitalier Universitaire de Nice [CHU Nice]
Moulis, Guillaume [Auteur]
Centre Hospitalier Universitaire de Toulouse [CHU Toulouse]
Rivière, Etienne [Auteur]
Hôpital Haut-Lévêque [CHU Bordeaux]
Le Gouellec, Noémie [Auteur]
Centre hospitalier [Valenciennes, Nord]
Raffray, Loïc [Auteur]
Centre Hospitalier Universitaire de La Réunion [CHU La Réunion]
Urbanski, Geoffrey [Auteur]
Centre Hospitalier Universitaire d'Angers [CHU Angers]
Sanges, Sébastien [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Maurier, François [Auteur]
Deroux, Alban [Auteur]
Centre Hospitalier Universitaire [CHU Grenoble] [CHUGA]
Mekinian, Arsène [Auteur]
CHU Saint-Antoine [AP-HP]
Monteiro, Renato [Auteur]
Centre de recherche sur l'Inflammation [CRI (UMR_S_1149 / ERL_8252 / U1149)]
Marcelli, Christian [Auteur]
Université de Caen Normandie - UFR Santé [UNICAEN Santé]
Guillevin, Loïc [Auteur]
Institut Cochin [IC UM3 (UMR 8104 / U1016)]
Maillot, François [Auteur]
Centre Hospitalier Régional Universitaire de Tours [CHRU Tours]
Lucas, Bruno [Auteur]
Institut Cochin [IC UM3 (UMR 8104 / U1016)]
Aouba, Achille [Auteur]
Université de Caen Normandie [UNICAEN]
Audemard-Verger, Alexandra [Auteur]
Centre Hospitalier Régional Universitaire de Tours [CHRU Tours]

Journal title :

Clinical Rheumatology

Abbreviated title :

Clin Rheumatol

Volume number :

41

Pages :

1483–1491

Publication date :

2022-01-19

ISSN :

1434-9949

English keyword(s) :

Gastrointestinal tract involvement
Henoch Schonlein purpura
IgA vasculitis
IL-1 beta
Joint involvement

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Objective Joint involvement can be observed during the course of adult IgA vasculitis (IgAV). However, clinical picture, prognosis, or pathophysiological data associated with this condition have been overlooked. We aimed ...
Show more >Objective Joint involvement can be observed during the course of adult IgA vasculitis (IgAV). However, clinical picture, prognosis, or pathophysiological data associated with this condition have been overlooked. We aimed to describe the clinical characteristics and outcome of IgAV patients with joint involvement and look to a specific cytokine profile. Methods We analyzed clinical and biological data from a nationwide study that included adult IgAV patients. Presentation and outcomes of patients with or without joint involvement were compared at baseline and during follow-up. Plasma cytokine measurements of IgAV patients included in a prospective study were also analyzed using multiplex assays. Results Among 260 patients, 62% had joint involvement. Among them, rheumatological manifestations included arthralgia (100%) or arthritis (16%), mostly involving the knees and ankles. In multivariate analysis, patients with joint involvement, compared to those without, were younger (p = 0.002; OR 0.87; 95% CI 0.80–0.95) and showed more frequent gastrointestinal tract involvement (p = 0.012; OR = 2.08; 95% CI 1.18–3.67). However, no difference in terms of clinical response, relapse, end-stage renal disease, or death was observed between groups. Among 13 cytokines measured, plasma interleukin (IL)-1β level was higher in patients with joint involvement compared to those without (mean ± SEM IL-1β, 3.5 ± 1.2 vs. 0.47 ± 0.1 pg/ml; p = 0.024) or healthy controls (vs. 1.2 ± 0.5 pg/ml; p = 0.076). Conclusion Joint involvement is frequent in adult IgAV and is associated with more frequent gastrointestinal involvement. Increased plasma IL-1β levels raise the question of targeting this cytokine in patients with chronic and/or refractory joint involvement.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-12T02:28:41Z
2024-03-04T09:54:39Z