Title :

Attenuated androgen discontinuation in patients with hereditary angioedema: a commented case series.

Author(s) :

Maurer, M. [Auteur]
Magerl, M. [Auteur]
Aygören-Pürsün, E. [Auteur]
Bork, K. [Auteur]
Farkas, H. [Auteur]
Longhurst, H. [Auteur]
Kiani-Alikhan, S. [Auteur]
Bouillet, Laurence [Auteur]
Centre Hospitalier Universitaire [CHU Grenoble] [CHUGA]
Centre de référence national des angiœdèmes [CREAK]
Boccon-Gibod, Isabelle [Auteur]
Centre Hospitalier Universitaire [CHU Grenoble] [CHUGA]
Centre de référence national des angiœdèmes [CREAK]
Cancian, M. [Auteur]
Zanichelli, A. [Auteur]
Launay, David [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Journal title :

Allergy, Asthma and Clinical Immunology

Abbreviated title :

Allergy Asthma Clin Immunol

Volume number :

18

Pages :

4

Publication date :

2022-01-15

ISSN :

1710-1484

English keyword(s) :

Angioedema
hereditary
Prophylaxis
Attenuated androgens
Danazol
Oxandrolone
Case series

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Background Hereditary angioedema (HAE) is characterized by potentially severe and life-threatening attacks of localized swelling. Prophylactic therapies are available, including attenuated androgens. Efficacy of attenuated ...
Show more >Background Hereditary angioedema (HAE) is characterized by potentially severe and life-threatening attacks of localized swelling. Prophylactic therapies are available, including attenuated androgens. Efficacy of attenuated androgens has not been assessed in large, randomized, placebo-controlled trials and can be associated with frequent, and sometimes severe, side effects. As better tolerated targeted therapies become available, attenuated androgen withdrawal is increasingly considered by physicians and their patients with HAE. Attenuated androgens withdrawal has not been systematically studied in HAE, although examination of other disorders indicates that attenuated androgen withdrawal may result in mood disturbances and flu-like symptoms. Standardized protocols for attenuated androgen discontinuation that continue to provide control of attacks while limiting potential attenuated androgen withdrawal symptoms are not established as the outcomes of different withdrawal strategies have not been compared. We aim to describe the challenges of attenuated androgen discontinuation in patients with HAE and how these may continue into the post-androgen period. Case presentation We present a retrospective case series of 10 patients with confirmed type I HAE who have discontinued prophylactic treatment with attenuated androgens. The most common reason for attenuated androgen discontinuation was side effects. Attenuated androgens were either immediately withdrawn, tapered and/or overlapped with another treatment. The major challenge of discontinuation was the management of an increased frequency and severity of HAE attacks in some patients. Conclusions Healthcare teams need to undertake careful planning and monitoring after attenuated androgens discontinuation, and modify treatment strategies if HAE control is destabilized with an increased number of attacks. Discontinuation of attenuated androgens is definitively an option in an evolving HAE treatment landscape, and outcomes can be favourable with additional patient support and education.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-12T02:30:02Z
2024-03-08T14:42:22Z
2024-03-08T14:43:21Z