Title :

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) : Series of 49 French pediatric cases.

Author(s) :

Bedouelle, Eve [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Ben Said, Benoit [Auteur]
Service d'immunologie [Centre Hospitalier Lyon Sud - HCL]
Tetart, F. [Auteur]
Service de Dermatologie [Rouen]
Milpied, B. [Auteur]
Service de dermatologie [Bordeaux]
Welfringer-Morin, A. [Auteur]
Centre de référence national des Maladies Génétiques à Expression Cutanée - National Reference Center for Genodermatoses and Rare Skin Diseases [MAGEC]
Service de Dermatologie [CHU-Necker]
Maruani, A. [Auteur]
Centre Hospitalier Régional Universitaire de Tours [CHRU Tours]
Université de Tours [UT]
MethodS in Patients-centered outcomes and HEalth ResEarch [SPHERE]
Catteau, Benoit [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Dezoteux, Frédéric [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Staumont, delphine [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Mazereeuw-Hautier, J. [Auteur]
Service Dermatologie [CHU Toulouse]
Abasq, C. [Auteur]
Centre Hospitalier Régional Universitaire de Brest [CHRU Brest]
Chiaverini, C. [Auteur]
Centre Hospitalier Universitaire de Nice [CHU Nice]
Service de Dermatologie [Nice]
Delaunay, J. [Auteur]
Centre Hospitalier Universitaire d'Angers [CHU Angers]
Mallet, S. [Auteur]
Hôpital de la Timone [CHU - APHM] [TIMONE]
Sterling, B. [Auteur]
Puzenat, E. [Auteur]
Centre Hospitalier Régional Universitaire de Besançon [CHRU Besançon]
Raynal, M. [Auteur]
CHU Rouen
Collet, E. [Auteur]
Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand [CHU Dijon]
Bernier, C. [Auteur]

Journal title :

Journal of Allergy and Clinical Immunology: In Practice

Abbreviated title :

J Allergy Clin Immunol Pract

Publication date :

2021-08-08

ISSN :

2213-2201

English keyword(s) :

Drug reaction with eosinophilia and systemic symptoms
DRESS
Pediatric
Children
Antibiotics
Antiepileptic drugs

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Background Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare and potentially fatal adverse reaction. It can be difficult to diagnose, even more so among children, because symptoms may mimic other ...
Show more >Background Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare and potentially fatal adverse reaction. It can be difficult to diagnose, even more so among children, because symptoms may mimic other commonly encountered pediatric conditions. Objective To describe clinical and laboratory features of DRESS syndrome in the pediatric population (age ≤18 years) and establish causative agents and treatment modalities. Methods This was a multicenter retrospective study of probable and definite DRESS cases (Registry of Sever Cutaneous Adverse Reaction score ≥ 4) in children hospitalized in 15 French university hospitals between 2000 and 2020. Results We included 49 cases. All children had fever and rash, 69.4% had lymphadenopathy, and 65.3% had facial edema. The most common organ affected was the liver (83.7%). Treatment consisted of topical corticosteroid in only 30.6% and systemic corticosteroid in 55.1%; 12.2% received intravenous immunoglobulin. Among probable and likely culprit drugs, 65% were antibiotics and 27.5% were antiepileptics, median time to DRESS symptom onset after initiation of 15 days (13 days with antibiotics and 21 days with antiepileptics). Twenty-seven children had allergy assessment for causative agents, 65.4% of whom had positive tests. Conclusions Culprit drugs are frequently antibiotics and antiepileptic drugs, and onset is often less than 2 weeks after treatment starts, especially with antibiotics. Treatment with topical corticosteroids appears to be sufficient in the least severe cases. Treatment by systemic corticosteroid therapy remains the reference treatment in case of severe organ damage.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-12T06:17:58Z
2024-03-01T13:17:11Z