Impaired renal function before kidney ...
Document type :
Article dans une revue scientifique: Article original
PMID :
Permalink :
Title :
Impaired renal function before kidney procurement has a deleterious impact on allograft survival in very old deceased kidney donors.
Author(s) :
Maanaoui, Mehdi [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Provôt, François [Auteur]
Service de Néphrologie et Transplantation rénale [CHRU-lille]
Bouyé, Sebastien [Auteur]
Service d'Urologie, andrologie et transplantation rénale [CHRU Lille]
Lionet, Arnaud [Auteur]
Service de Néphrologie et Transplantation rénale [CHRU-lille]
Lenain, Remi [Auteur]
Service de Néphrologie et Transplantation rénale [CHRU-lille]
Fages, Victor [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Frimat, Marie [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Lebas, Céline [Auteur]
Service de Néphrologie et Transplantation rénale [CHRU-lille]
Glowacki, Francois [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - EA 4483
Hazzan, Marc [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Recherche translationnelle sur le diabète - U 1190 [RTD]
Provôt, François [Auteur]
Service de Néphrologie et Transplantation rénale [CHRU-lille]
Bouyé, Sebastien [Auteur]
Service d'Urologie, andrologie et transplantation rénale [CHRU Lille]
Lionet, Arnaud [Auteur]
Service de Néphrologie et Transplantation rénale [CHRU-lille]
Lenain, Remi [Auteur]
Service de Néphrologie et Transplantation rénale [CHRU-lille]
Fages, Victor [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Frimat, Marie [Auteur]

Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Lebas, Céline [Auteur]
Service de Néphrologie et Transplantation rénale [CHRU-lille]
Glowacki, Francois [Auteur]

IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - EA 4483
Hazzan, Marc [Auteur]

Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Journal title :
Scientific Reports
Abbreviated title :
Sci Rep
Volume number :
11
Pages :
12226
Publication date :
2021-06-19
ISSN :
2045-2322
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
As the use of elderly kidney donors for transplantation is increasing with time, there is a need to understand which factors impact on their prognosis. No data exist on the impact of an impaired renal function (IRF) in ...
Show more >As the use of elderly kidney donors for transplantation is increasing with time, there is a need to understand which factors impact on their prognosis. No data exist on the impact of an impaired renal function (IRF) in such population. 116 kidney recipients from deceased kidney donors over 70 years were included from 2005 to 2015 in a single-center retrospective study. IRF before organ procurement was defined as a serum creatinine above 1.0 mg/dl or a transient episode of oligo-anuria. Mean ages for donors and recipients were respectively 74.8 ± 3.5 and 66.7 ± 8.0. Graft survival censored for death at 5 years was of 77%. Using a multivariate analysis by Cox model, the only predictor of graft loss present in the donor was IRF before organ procurement (HR 4.2 CI95[1.8–9.7]). IRF was also associated with significant lower estimated glomerular filtration rates up to 1 year post-transplantation. By contrast, KDPI score (median of 98 [96–100]), was not associated with the risk of graft failure. Then, IRF before kidney procurement may define a risk subgroup among very-old deceased kidney donors, in whom pre-implantatory biopsies, dual kidney transplantation or calcineurin inhibitor-free immunosuppressive regimen could help to improve outcomes.Show less >
Show more >As the use of elderly kidney donors for transplantation is increasing with time, there is a need to understand which factors impact on their prognosis. No data exist on the impact of an impaired renal function (IRF) in such population. 116 kidney recipients from deceased kidney donors over 70 years were included from 2005 to 2015 in a single-center retrospective study. IRF before organ procurement was defined as a serum creatinine above 1.0 mg/dl or a transient episode of oligo-anuria. Mean ages for donors and recipients were respectively 74.8 ± 3.5 and 66.7 ± 8.0. Graft survival censored for death at 5 years was of 77%. Using a multivariate analysis by Cox model, the only predictor of graft loss present in the donor was IRF before organ procurement (HR 4.2 CI95[1.8–9.7]). IRF was also associated with significant lower estimated glomerular filtration rates up to 1 year post-transplantation. By contrast, KDPI score (median of 98 [96–100]), was not associated with the risk of graft failure. Then, IRF before kidney procurement may define a risk subgroup among very-old deceased kidney donors, in whom pre-implantatory biopsies, dual kidney transplantation or calcineurin inhibitor-free immunosuppressive regimen could help to improve outcomes.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
Inserm
CHU Lille
Inserm
CHU Lille
Collections :
Submission date :
2024-01-12T06:46:50Z
2024-01-26T09:22:15Z
2024-01-26T09:22:15Z
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