Titre :

Maternal stress alters endocrine function of the feto-placental unit in rats.

Auteur(s) :

Mairesse, Jérôme [Auteur]
Lesage, Jean [Auteur]
Breton, Christophe [Auteur]
Bréant, Bernadette [Auteur]
Hahn, Tom [Auteur]
Darnaudéry, Muriel [Auteur]
Dickson, Suzanne L [Auteur]
Seckl, Jonathan [Auteur]
Blondeau, Bertrand [Auteur]
Vieau, didier [Auteur]
Maccari, Stefania [Auteur]
Viltart, Odile [Auteur]
Institut Pasteur de Lille

Titre de la revue :

American journal of physiology. Endocrinology and metabolism

Nom court de la revue :

Am J Physiol Endocrinol Metab

Numéro :

292

Pagination :

E1526-33

Date de publication :

2007-06-01

ISSN :

0193-1849

Mot(s)-clé(s) en anglais :

11-beta-Hydroxysteroid Dehydrogenase Type 2
Adrenal Glands
Animals
Blood Glucose
Body Weight
Chronic Disease
Eating
Endocrine Glands
Female
Fetal Blood
Fetus
Glucose Transport Proteins, Facilitative
Hormones
Insulin-Secreting Cells
Islets of Langerhans
Male
Organ Size
Pancreas
Placenta
Pregnancy
Pregnancy Complications
Rats
Restraint, Physical
Stress, Physiological
Testis

Discipline(s) HAL :

Sciences cognitives

Résumé en anglais : [en]

Prenatal stress (PS) can cause early and long-term developmental effects resulting in part from altered maternal and/or fetal glucocorticoid exposure. The aim of the present study was to assess the impact of chronic restraint ...
Lire la suite >Prenatal stress (PS) can cause early and long-term developmental effects resulting in part from altered maternal and/or fetal glucocorticoid exposure. The aim of the present study was to assess the impact of chronic restraint stress during late gestation on feto-placental unit physiology and function in embryonic (E) day 21 male rat fetuses. Chronic stress decreased body weight gain and food intake of the dams and increased their adrenal weight. In the placenta of PS rats, the expression of glucose transporter type 1 (GLUT1) was decreased, whereas GLUT3 and GLUT4 were slightly increased. Moreover, placental expression and activity of the glucocorticoid "barrier" enzyme 11beta-hydroxysteroid dehydrogenase type 2 was strongly reduced. At E21, PS fetuses exhibited decreased body, adrenal pancreas, and testis weights. These alterations were associated with reduced pancreatic beta-cell mass, plasma levels of glucose, growth hormone, and ACTH, whereas corticosterone, insulin, IGF-1, and CBG levels were unaffected. These data emphasize the impact of PS on both fetal growth and endocrine function as well as on placental physiology, suggesting that PS could program processes implied in adult biology and pathophysiology.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CNRS
CHU Lille

Collections :

• Autres travaux scientifiques

Date de dépôt :

2024-01-12T14:37:03Z
2024-02-28T11:50:06Z