Title :

Maternal stress alters endocrine function of the feto-placental unit in rats.

Author(s) :

Mairesse, Jérôme [Auteur]
Lesage, Jean [Auteur]
Breton, Christophe [Auteur]
Bréant, Bernadette [Auteur]
Hahn, Tom [Auteur]
Darnaudéry, Muriel [Auteur]
Dickson, Suzanne L [Auteur]
Seckl, Jonathan [Auteur]
Blondeau, Bertrand [Auteur]
Vieau, didier [Auteur]
Maccari, Stefania [Auteur]
Viltart, Odile [Auteur]
Institut Pasteur de Lille

Journal title :

American journal of physiology. Endocrinology and metabolism

Abbreviated title :

Am J Physiol Endocrinol Metab

Volume number :

292

Pages :

E1526-33

Publication date :

2007-06-01

ISSN :

0193-1849

English keyword(s) :

11-beta-Hydroxysteroid Dehydrogenase Type 2
Adrenal Glands
Animals
Blood Glucose
Body Weight
Chronic Disease
Eating
Endocrine Glands
Female
Fetal Blood
Fetus
Glucose Transport Proteins, Facilitative
Hormones
Insulin-Secreting Cells
Islets of Langerhans
Male
Organ Size
Pancreas
Placenta
Pregnancy
Pregnancy Complications
Rats
Restraint, Physical
Stress, Physiological
Testis

HAL domain(s) :

Sciences cognitives

English abstract : [en]

Prenatal stress (PS) can cause early and long-term developmental effects resulting in part from altered maternal and/or fetal glucocorticoid exposure. The aim of the present study was to assess the impact of chronic restraint ...
Show more >Prenatal stress (PS) can cause early and long-term developmental effects resulting in part from altered maternal and/or fetal glucocorticoid exposure. The aim of the present study was to assess the impact of chronic restraint stress during late gestation on feto-placental unit physiology and function in embryonic (E) day 21 male rat fetuses. Chronic stress decreased body weight gain and food intake of the dams and increased their adrenal weight. In the placenta of PS rats, the expression of glucose transporter type 1 (GLUT1) was decreased, whereas GLUT3 and GLUT4 were slightly increased. Moreover, placental expression and activity of the glucocorticoid "barrier" enzyme 11beta-hydroxysteroid dehydrogenase type 2 was strongly reduced. At E21, PS fetuses exhibited decreased body, adrenal pancreas, and testis weights. These alterations were associated with reduced pancreatic beta-cell mass, plasma levels of glucose, growth hormone, and ACTH, whereas corticosterone, insulin, IGF-1, and CBG levels were unaffected. These data emphasize the impact of PS on both fetal growth and endocrine function as well as on placental physiology, suggesting that PS could program processes implied in adult biology and pathophysiology.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CNRS
CHU Lille

Collections :

• Autres travaux scientifiques

Submission date :

2024-01-12T14:37:03Z
2024-02-28T11:50:06Z