Title :

Confinement to the open arm of the elevated-plus maze as anxiety paradigm: behavioral validation.

Author(s) :

Salomé, Nicolas [Auteur]
Landgraf, Rainer [Auteur]
Viltart, Odile [Auteur]
Université de Lille, Sciences et Technologies

Journal title :

Behavioral Neuroscience

Abbreviated title :

Behav Neurosci

Volume number :

120

Pages :

719-23

Publication date :

2006-06-01

ISSN :

1939-0084

English keyword(s) :

Animals
Anxiety
Behavior, Animal
Discriminant Analysis
Disease Models, Animal
Male
Maze Learning
Motor Activity
Principal Component Analysis
Rats
Rats, Wistar
Statistics, Nonparametric

HAL domain(s) :

Sciences cognitives

English abstract : [en]

Exposure to the open arm of the elevated-plus maze was used to assess the neurobiological correlates of anxiety in the high-anxiety-related behavior (HAB) and low-anxiety-related behavior (LAB) rat lines. The authors sought ...
Show more >Exposure to the open arm of the elevated-plus maze was used to assess the neurobiological correlates of anxiety in the high-anxiety-related behavior (HAB) and low-anxiety-related behavior (LAB) rat lines. The authors sought to determine whether this mild stressor could be considered a valuable anxiety test revealing specific behavioral differences. Behavioral parameters scored were submitted to a discriminant and factor analysis to investigate emotional parameters discriminating HAB and LAB rats. Principal component analysis showed that the HAB rats' behavior was driven by anxiety, whereas the LAB rats' behavior was mainly explained by locomotor activity. Moreover, the rats displayed behaviors that reflected distinct coping strategies confirming anxiogenic open arm effects and differential appraisals of the stressor dependent on the genetic predisposition to either hyper- or hypo-anxiety.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CNRS
CHU Lille

Collections :

• Autres travaux scientifiques

Submission date :

2024-01-12T14:40:57Z
2024-02-23T11:48:28Z