Interleukin-7, a new cytokine targeting ...
Type de document :
Article dans une revue scientifique: Article original
PMID :
URL permanente :
Titre :
Interleukin-7, a new cytokine targeting the mouse hypothalamic arcuate nucleus: role in body weight and food intake regulation
Auteur(s) :
Macia, Laurence [Auteur]
Viltart, Odile [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U1172 Inserm - U837 [JPArc]
Delacre, Myriam [Auteur]
Institut Pasteur de Lille
Sachot, Christelle [Auteur]
Héliot, Laurent [Auteur]
Di Santo, James P [Auteur]
Institut Pasteur [Paris] [IP]
Wolowczuk, Isabelle [Auteur]
Institut Pasteur de Lille
Viltart, Odile [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U1172 Inserm - U837 [JPArc]
Delacre, Myriam [Auteur]
Institut Pasteur de Lille
Sachot, Christelle [Auteur]
Héliot, Laurent [Auteur]
Di Santo, James P [Auteur]
Institut Pasteur [Paris] [IP]
Wolowczuk, Isabelle [Auteur]
Institut Pasteur de Lille
Titre de la revue :
PLoS ONE
Nom court de la revue :
PLoS One
Numéro :
5
Pagination :
e9953
Date de publication :
2010-04-01
ISSN :
1932-6203
Mot(s)-clé(s) en anglais :
Animals
Appetite Regulation
Body Weight
Brain Chemistry
Hypothalamus
Interleukin-7
Mice
Neurons
Obesity
Phosphorylation
Receptors, Interleukin-7
STAT3 Transcription Factor
Appetite Regulation
Body Weight
Brain Chemistry
Hypothalamus
Interleukin-7
Mice
Neurons
Obesity
Phosphorylation
Receptors, Interleukin-7
STAT3 Transcription Factor
Discipline(s) HAL :
Sciences cognitives
Résumé en anglais : [en]
Body weight is controlled through peripheral (white adipose tissue) and central (mainly hypothalamus) mechanisms. We have recently obtained evidence that overexpression of interleukin (IL)-7, a critical cytokine involved ...
Lire la suite >Body weight is controlled through peripheral (white adipose tissue) and central (mainly hypothalamus) mechanisms. We have recently obtained evidence that overexpression of interleukin (IL)-7, a critical cytokine involved in lymphopoiesis, can protect against the development of diet-induced obesity in mice. Here we assessed whether IL-7 mediated its effects by modulating hypothalamic function. Acute subcutaneous injection of IL-7 prevented monosodium glutamate-induced obesity, this being correlated with partial protection against cell death in the hypothalamic arcuate nucleus (ARC). Moreover, we showed that IL-7 activated hypothalamic areas involved in regulation of feeding behavior, as indicated by induction of the activation marker c-Fos in neural cells located in the ventromedial part of the ARC and by inhibition of food intake after fasting. Both chains of the IL-7 receptor (IL-7Ralpha and gamma(c)) were expressed in the ARC and IL-7 injection induced STAT-3 phosphorylation in this area. Finally, we established that IL-7 modulated the expression of neuropeptides that tune food intake, with a stimulatory effect on the expression of pro-opiomelanocortin and an inhibitory effect on agouti-related peptide expression in accordance with IL-7 promoting anorectic effects. These results suggest that the immunomodulatory cytokine IL-7 plays an important and unappreciated role in hypothalamic body weight regulation.Lire moins >
Lire la suite >Body weight is controlled through peripheral (white adipose tissue) and central (mainly hypothalamus) mechanisms. We have recently obtained evidence that overexpression of interleukin (IL)-7, a critical cytokine involved in lymphopoiesis, can protect against the development of diet-induced obesity in mice. Here we assessed whether IL-7 mediated its effects by modulating hypothalamic function. Acute subcutaneous injection of IL-7 prevented monosodium glutamate-induced obesity, this being correlated with partial protection against cell death in the hypothalamic arcuate nucleus (ARC). Moreover, we showed that IL-7 activated hypothalamic areas involved in regulation of feeding behavior, as indicated by induction of the activation marker c-Fos in neural cells located in the ventromedial part of the ARC and by inhibition of food intake after fasting. Both chains of the IL-7 receptor (IL-7Ralpha and gamma(c)) were expressed in the ARC and IL-7 injection induced STAT-3 phosphorylation in this area. Finally, we established that IL-7 modulated the expression of neuropeptides that tune food intake, with a stimulatory effect on the expression of pro-opiomelanocortin and an inhibitory effect on agouti-related peptide expression in accordance with IL-7 promoting anorectic effects. These results suggest that the immunomodulatory cytokine IL-7 plays an important and unappreciated role in hypothalamic body weight regulation.Lire moins >
Langue :
Anglais
Comité de lecture :
Oui
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
Université de Lille
CNRS
CHU Lille
CNRS
CHU Lille
Collections :
Date de dépôt :
2024-01-12T14:45:14Z
2024-02-28T12:38:35Z
2024-02-28T12:38:35Z
Fichiers
- Macia Viltart et al. 2010 PlOsOne.pdf
- Version éditeur
- Accès libre
- Accéder au document