Title :

Altered hypothalamo-pituitary-adrenal and sympatho-adrenomedullary activities in rats bred for high anxiety: central and peripheral correlates

Author(s) :

Salomé, Nicolas [Auteur]
Viltart, Odile [Auteur]
Université de Lille, Sciences et Technologies
Lesage, Jean [Auteur]
Université de Lille, Sciences et Technologies
Landgraf, Rainer [Auteur]
Vieau, didier [Auteur]
Université de Lille, Sciences et Technologies
Laborie, Christine [Auteur]
Université de Lille, Sciences et Technologies

Journal title :

Psychoneuroendocrinology

Volume number :

31

Pages :

724-35

Publication date :

2006-07-01

ISSN :

0306-4530

English keyword(s) :

Adrenal Glands
Adrenocorticotropic Hormone
Amygdala
Animals
Anxiety
Biogenic Monoamines
Corticosterone
Hypothalamo-Hypophyseal System
Male
Neurosecretory Systems
Organ Size
Phenylethanolamine N-Methyltransferase
Pituitary Gland, Anterior
Pituitary-Adrenal System
RNA, Messenger
Rats
Rats, Wistar
Septum of Brain
Species Specificity
Sympathetic Nervous System
Tyrosine 3-Monooxygenase

HAL domain(s) :

Sciences cognitives

English abstract : [en]

Wistar rats have been selectively bred for high (HABs) or low (LABs) anxiety-related behavior based on results obtained in the elevated-plus maze. They also display robust behavioral differences in a variety of additional ...
Show more >Wistar rats have been selectively bred for high (HABs) or low (LABs) anxiety-related behavior based on results obtained in the elevated-plus maze. They also display robust behavioral differences in a variety of additional anxiety tests. The present study was undertaken to further characterize physiological substrates that contribute to the expression of this anxious trait. We report changes in brain and peripheral structures involved in the regulation of both the hypothalamo-pituitary-adrenal (HPA) and sympatho-adrenal systems. Following exposure to a mild stressor, HABs displayed a hyper-reactivity of the HPA axis associated with a hypo-reactivity of the sympatho-adrenal system and a lower serotonin turnover in the lateral septum and amygdala. At rest, HABs showed a higher adrenal weight and lower tyrosine hydroxylase and phenylethanolamine-N-methyltransferase mRNAs expression in their adrenals than LABs. In the anterior pituitary, HABs also exhibited increased proopiomelanocortin and decreased vasopressin V1b receptor mRNAs expression, whereas glucocorticoid receptor mRNA levels remained unchanged. These results indicate that the behavioral phenotype of HABs is associated with peripheral and central alterations of endocrine mechanisms involved in stress response regulation. Data are discussed in relation to coping strategies adopted to manage stressful situations. In conclusion, HABs can be considered as an useful model to study the etiology and pathophysiology of stress-related disorders and their neuroendocrine substrates.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CNRS
CHU Lille

Collections :

• Autres travaux scientifiques

Submission date :

2024-01-12T14:53:54Z
2024-02-28T11:54:09Z