Endemic parkinsonism: clusters, biology ...
Document type :
Article dans une revue scientifique: Article de synthèse/Review paper
PMID :
Permalink :
Title :
Endemic parkinsonism: clusters, biology and clinical features
Author(s) :
Menšíková, K. [Auteur]
Palacky University Olomouc
Steele, J. C. [Auteur]
Rosales, R. [Auteur]
University of Santo Tomas [Manila, Philippines]
Colosimo, C. [Auteur]
Ospedale "Santa Maria della Misericordia" = University Hospital "Santa Maria della Misericordia"
Spencer, P. [Auteur]
Oregon Health and Science University [Portland] [OHSU]
Lannuzel, A. [Auteur]
CHU Pointe-à-Pitre / Abymes [Guadeloupe]
Ugawa, Y. [Auteur]
Sasaki, R. [Auteur]
Giménez-Roldán, S. [Auteur]
Matej, R. [Auteur]
Tuckova, L. [Auteur]
Hrabos, D. [Auteur]
Kolarikova, K. [Auteur]
Vodicka, R. [Auteur]
Vrtel, R. [Auteur]
Strnad, M. [Auteur]
Hlustik, P. [Auteur]
Otruba, P. [Auteur]
Prochazka, M. [Auteur]
Bares, M. [Auteur]
Boluda, S. [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Buee, Luc [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Ransmayr, G. [Auteur]
Kaňovský, P. [Auteur]
Palacky University Olomouc
Steele, J. C. [Auteur]
Rosales, R. [Auteur]
University of Santo Tomas [Manila, Philippines]
Colosimo, C. [Auteur]
Ospedale "Santa Maria della Misericordia" = University Hospital "Santa Maria della Misericordia"
Spencer, P. [Auteur]
Oregon Health and Science University [Portland] [OHSU]
Lannuzel, A. [Auteur]
CHU Pointe-à-Pitre / Abymes [Guadeloupe]
Ugawa, Y. [Auteur]
Sasaki, R. [Auteur]
Giménez-Roldán, S. [Auteur]
Matej, R. [Auteur]
Tuckova, L. [Auteur]
Hrabos, D. [Auteur]
Kolarikova, K. [Auteur]
Vodicka, R. [Auteur]
Vrtel, R. [Auteur]
Strnad, M. [Auteur]
Hlustik, P. [Auteur]
Otruba, P. [Auteur]
Prochazka, M. [Auteur]
Bares, M. [Auteur]
Boluda, S. [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Buee, Luc [Auteur]

Lille Neurosciences & Cognition (LilNCog) - U 1172
Ransmayr, G. [Auteur]
Kaňovský, P. [Auteur]
Journal title :
Nature Reviews Neurology
Abbreviated title :
Nat Rev Neurol
Publication date :
2023-09-12
ISSN :
1759-4766
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
The term ‘endemic parkinsonism’ refers to diseases that manifest with a dominant parkinsonian syndrome, which can be typical or atypical, and are present only in a particular geographically defined location or population. ...
Show more >The term ‘endemic parkinsonism’ refers to diseases that manifest with a dominant parkinsonian syndrome, which can be typical or atypical, and are present only in a particular geographically defined location or population. Ten phenotypes of endemic parkinsonism are currently known: three in the Western Pacific region; two in the Asian-Oceanic region; one in the Caribbean islands of Guadeloupe and Martinique; and four in Europe. Some of these disease entities seem to be disappearing over time and therefore are probably triggered by unique environmental factors. By contrast, other types persist because they are exclusively genetically determined. Given the geographical clustering and potential overlap in biological and clinical features of these exceptionally interesting diseases, this Review provides a historical reference text and offers current perspectives on each of the 10 phenotypes of endemic parkinsonism. Knowledge obtained from the study of these disease entities supports the hypothesis that both genetic and environmental factors contribute to the development of neurodegenerative diseases, not only in endemic parkinsonism but also in general. At the same time, this understanding suggests useful directions for further research in this area.Show less >
Show more >The term ‘endemic parkinsonism’ refers to diseases that manifest with a dominant parkinsonian syndrome, which can be typical or atypical, and are present only in a particular geographically defined location or population. Ten phenotypes of endemic parkinsonism are currently known: three in the Western Pacific region; two in the Asian-Oceanic region; one in the Caribbean islands of Guadeloupe and Martinique; and four in Europe. Some of these disease entities seem to be disappearing over time and therefore are probably triggered by unique environmental factors. By contrast, other types persist because they are exclusively genetically determined. Given the geographical clustering and potential overlap in biological and clinical features of these exceptionally interesting diseases, this Review provides a historical reference text and offers current perspectives on each of the 10 phenotypes of endemic parkinsonism. Knowledge obtained from the study of these disease entities supports the hypothesis that both genetic and environmental factors contribute to the development of neurodegenerative diseases, not only in endemic parkinsonism but also in general. At the same time, this understanding suggests useful directions for further research in this area.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
Inserm
CHU Lille
Inserm
CHU Lille
Collections :
Submission date :
2024-01-15T22:29:08Z
2024-09-02T15:08:48Z
2024-09-02T15:08:48Z