Functional connectivity and glutamate ...
Document type :
Article dans une revue scientifique: Article original
PMID :
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Title :
Functional connectivity and glutamate levels of the medial prefrontal cortex in schizotypy are related to sensory amplification in a probabilistic reasoning task.
Author(s) :
Derome, Mélodie [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Kozuharova, Petya [Auteur]
Diaconescu, Andreea [Auteur]
Denève, Sophie [Auteur]
Jardri, Renaud [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Allen, Paul [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Kozuharova, Petya [Auteur]
Diaconescu, Andreea [Auteur]
Denève, Sophie [Auteur]
Jardri, Renaud [Auteur]

Lille Neurosciences & Cognition (LilNCog) - U 1172
Allen, Paul [Auteur]
Journal title :
NeuroImage
Volume number :
278
Pages :
120280
Publication date :
2023-09
ISSN :
1095-9572
Keyword(s) :
Psychosis spectrum disorders
Spectroscopy
Neuroimaging
Circular Inference
Spectroscopy
Neuroimaging
Circular Inference
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
The circular inference (CI) computational model assumes a corruption of sensory data by prior information and vice versa, leading at the extremes to 'see what we expect' (through prior amplification) and/or to 'expect what ...
Show more >The circular inference (CI) computational model assumes a corruption of sensory data by prior information and vice versa, leading at the extremes to 'see what we expect' (through prior amplification) and/or to 'expect what we see' (through sensory amplification). Although a CI mechanism has been reported in a schizophrenia population, it has not been investigated in individuals experiencing psychosis-like experiences, such as people with high schizotypy traits. Furthermore, the neurobiological basis of CI, such as the link between hierarchical amplifications, excitatory neurotransmission, and resting state functional connectivity (RSFC), remains untested. The participants included in the present study consisted of a subsample of those recruited in a study previously published by our group, Kozhuharova et al. (2021b). We included 36 participants with High (n=18) and Low (n=18) levels of schizotypy who completed a probabilistic reasoning task (the Fisher task) for which individual confidence levels were obtained and fitted to the CI model. Participants also underwent a 1H-Magnetic Resonance Spectroscopy (MRS) scan to measure medial prefrontal cortex (mPFC) glutamate metabolite levels, and a functional Magnetic Resonance Imaging (fMRI) scan to measure RSFC of the medial prefrontal cortex (mPFC). People with high levels of schizotypy exhibited changes in CI parameters, altered cortical excitatory neurotransmission and RSFC that were all associated with sensory amplification. Our findings capture a multimodal signature of CI that is observable in people early in the psychosis spectrum.Show less >
Show more >The circular inference (CI) computational model assumes a corruption of sensory data by prior information and vice versa, leading at the extremes to 'see what we expect' (through prior amplification) and/or to 'expect what we see' (through sensory amplification). Although a CI mechanism has been reported in a schizophrenia population, it has not been investigated in individuals experiencing psychosis-like experiences, such as people with high schizotypy traits. Furthermore, the neurobiological basis of CI, such as the link between hierarchical amplifications, excitatory neurotransmission, and resting state functional connectivity (RSFC), remains untested. The participants included in the present study consisted of a subsample of those recruited in a study previously published by our group, Kozhuharova et al. (2021b). We included 36 participants with High (n=18) and Low (n=18) levels of schizotypy who completed a probabilistic reasoning task (the Fisher task) for which individual confidence levels were obtained and fitted to the CI model. Participants also underwent a 1H-Magnetic Resonance Spectroscopy (MRS) scan to measure medial prefrontal cortex (mPFC) glutamate metabolite levels, and a functional Magnetic Resonance Imaging (fMRI) scan to measure RSFC of the medial prefrontal cortex (mPFC). People with high levels of schizotypy exhibited changes in CI parameters, altered cortical excitatory neurotransmission and RSFC that were all associated with sensory amplification. Our findings capture a multimodal signature of CI that is observable in people early in the psychosis spectrum.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
Inserm
CHU Lille
Inserm
CHU Lille
Collections :
Submission date :
2024-01-15T22:38:10Z
2024-12-17T13:59:23Z
2024-12-17T13:59:23Z
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