Title :

Enteric synucleinopathy: from trendy concept to real entity.

Author(s) :

De Guilhem De Lataillade, Adrien [Auteur]
The Enteric Nervous System in gut and brain disorders [U1235] [TENS]
Lebouvier, Thibaud [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Noble, Wendy [Auteur]
Institute of Psychiatry, Psychology & Neuroscience, King's College London
Leclair-Visonneau, Laurene [Auteur]
The Enteric Nervous System in gut and brain disorders [U1235] [TENS]
Derkinderen, Pascal [Auteur]
The Enteric Nervous System in gut and brain disorders [U1235] [TENS]

Journal title :

Free Neuropathology

Volume number :

1

Publication date :

2023-06-08

ISSN :

2699-4445

English keyword(s) :

Synucleinopathies
Tauopathies
Enteric nervous system
Aggregates
Alpha-synuclein
Parkinson’s disease

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

An accumulating body of literature has emerged in the past 25 years to show that Parkinson’s disease (PD) is not only a disorder of the brain but also of the gastrointestinal tract and more generally of the gut-brain axis. ...
Show more >An accumulating body of literature has emerged in the past 25 years to show that Parkinson’s disease (PD) is not only a disorder of the brain but also of the gastrointestinal tract and more generally of the gut-brain axis. Gastrointestinal symptoms occur in almost every PD patient at some point and in nearly every case examined pathologically autopsy studies find alpha-synuclein deposits, the pathological hallmarks of PD, in the enteric nervous system. This concept of ‘enteric synucleinopathy’ led to the hypothesis that the enteric nervous system might play a pivotal role in the initiation and spreading of PD. Although this hypothesis opens up interesting perspectives on the pathogenesis of neurodegenerative disorders, some important questions are still pending. The present opinion paper describes and compares the physiological and pathophysiological properties of alpha-synuclein in the brain and the enteric nervous system. We conclude that the existing data supports the existence of pathological alpha-synuclein species in the gut in PD. We also discuss if gut-brain interactions are important in other neurodegenerative disorders.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Submission date :

2024-01-15T22:52:39Z
2024-06-14T06:46:53Z