Diffusion-Weighted Imaging Lesion Reversal ...
Document type :
Article dans une revue scientifique: Article original
PMID :
Permalink :
Title :
Diffusion-Weighted Imaging Lesion Reversal in Older Patients With Stroke Treated With Mechanical Thrombectomy.
Author(s) :
Benzakoun, Joseph [Auteur]
Institut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
Ben Hassen, Wagih [Auteur]
Institut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
Bretzner, Martin [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Puy, Laurent [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Turc, Guillaume [Auteur]
Institut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
Boulouis, Grégoire [Auteur]
CHU Trousseau [Tours]
Oppenheim, Catherine [Auteur]
Institut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
Naggara, Olivier [Auteur]
Institut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
Cordonnier, Charlotte [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Henon, Hilde [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Pasi, Marco [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Institut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
Ben Hassen, Wagih [Auteur]
Institut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
Bretzner, Martin [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Puy, Laurent [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Turc, Guillaume [Auteur]
Institut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
Boulouis, Grégoire [Auteur]
CHU Trousseau [Tours]
Oppenheim, Catherine [Auteur]
Institut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
Naggara, Olivier [Auteur]
Institut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
Cordonnier, Charlotte [Auteur]

Lille Neurosciences & Cognition (LilNCog) - U 1172
Henon, Hilde [Auteur]

Lille Neurosciences & Cognition (LilNCog) - U 1172
Pasi, Marco [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Journal title :
Stroke
Volume number :
54
Pages :
1823–1829
Publisher :
American Heart Association
Publication date :
2023-05-20
ISSN :
1524-4628
Keyword(s) :
aging
ischemic stroke
magnetic resonance imaging
thrombectomy
ischemic stroke
magnetic resonance imaging
thrombectomy
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
BACKGROUND:
Diffusion-weighted imaging lesion reversal (DWIR) is frequently observed after mechanical thrombectomy for acute ischemic stroke, but little is known about age-related differences and impact on outcome. We ...
Show more >BACKGROUND: Diffusion-weighted imaging lesion reversal (DWIR) is frequently observed after mechanical thrombectomy for acute ischemic stroke, but little is known about age-related differences and impact on outcome. We aimed to compare, in patients <80 versus ≥80 years old, (1) the effect of successful recanalization on DWIR and (2) the impact of DWIR on functional outcome. METHODS: We retrospectively analyzed data of patients treated for an anterior circulation acute ischemic stroke with large vessel occlusion in 2 French hospitals, who underwent baseline and 24-hour follow-up magnetic resonance imaging, with baseline DWI lesion volume ≥10 cc. The percentage of DWIR (DWIR%), was calculated as follows: DWIR%=(DWIR volume/baseline DWI volume)×100. Data on demographics, medical history, and baseline clinical and radiological characteristics were collected. RESULTS: Among 433 included patients (median age, 68 years), median DWIR% after mechanical thrombectomy was 22% (6–35) in patients ≥80, and 19% (interquartile range, 10–34) in patients <80 (P=0.948). In multivariable analyses, successful recanalization after mechanical thrombectomy was associated with higher median DWIR% in both ≥80 (P=0.004) and <80 (P=0.002) patients. In subgroup analyses performed on a minority of subjects, collateral vessels status score (n=87) and white matter hyperintensity volume (n=131) were not associated with DWIR% (P>0.2). In multivariable analyses, DWIR% was associated with increased rates of favorable 3-month outcomes in both ≥80 (P=0.003) and <80 (P=0.013) patients; the effect of DWIR% on outcome was not influenced by the age group (P interaction=0.185) CONCLUSIONS: DWIR might be an important and nonage-dependent effect of arterial recanalization, as it seems to beneficially impact 3-month outcomes of both younger and older subjects treated with mechanical thrombectomy for acute ischemic stroke and large vessel occlusion.Show less >
Show more >BACKGROUND: Diffusion-weighted imaging lesion reversal (DWIR) is frequently observed after mechanical thrombectomy for acute ischemic stroke, but little is known about age-related differences and impact on outcome. We aimed to compare, in patients <80 versus ≥80 years old, (1) the effect of successful recanalization on DWIR and (2) the impact of DWIR on functional outcome. METHODS: We retrospectively analyzed data of patients treated for an anterior circulation acute ischemic stroke with large vessel occlusion in 2 French hospitals, who underwent baseline and 24-hour follow-up magnetic resonance imaging, with baseline DWI lesion volume ≥10 cc. The percentage of DWIR (DWIR%), was calculated as follows: DWIR%=(DWIR volume/baseline DWI volume)×100. Data on demographics, medical history, and baseline clinical and radiological characteristics were collected. RESULTS: Among 433 included patients (median age, 68 years), median DWIR% after mechanical thrombectomy was 22% (6–35) in patients ≥80, and 19% (interquartile range, 10–34) in patients <80 (P=0.948). In multivariable analyses, successful recanalization after mechanical thrombectomy was associated with higher median DWIR% in both ≥80 (P=0.004) and <80 (P=0.002) patients. In subgroup analyses performed on a minority of subjects, collateral vessels status score (n=87) and white matter hyperintensity volume (n=131) were not associated with DWIR% (P>0.2). In multivariable analyses, DWIR% was associated with increased rates of favorable 3-month outcomes in both ≥80 (P=0.003) and <80 (P=0.013) patients; the effect of DWIR% on outcome was not influenced by the age group (P interaction=0.185) CONCLUSIONS: DWIR might be an important and nonage-dependent effect of arterial recanalization, as it seems to beneficially impact 3-month outcomes of both younger and older subjects treated with mechanical thrombectomy for acute ischemic stroke and large vessel occlusion.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
Inserm
CHU Lille
Inserm
CHU Lille
Collections :
Submission date :
2024-01-15T22:59:19Z
2024-07-10T07:00:10Z
2024-07-10T07:00:10Z