Titre :

Alzheimer PHF-tau aggregates do not spread tau pathology to the brain via the Retino-tectal projection after intraocular injection in mouse models

Auteur(s) :

De Fisenne, Marie Ange [Auteur]
Yilmaz, Zehra [Auteur]
De Decker, Robert [Auteur]
Suain, Valérie [Auteur]
Buee, Luc [Auteur]
Inserm UMR837 Team 5
Ando, Kunie [Auteur]
Brion, Jean-Pierre [Auteur]
Leroy, Karelle [Auteur]

Titre de la revue :

Neurobiology of Disease

Nom court de la revue :

Neurobiol Dis

Numéro :

174

Pagination :

105875

Éditeur :

Elsevier

Date de publication :

2022-09-22

ISSN :

1095-953X

Mot(s)-clé(s) en anglais :

Neurofibrillary tangles
Intraocular injection
Transgenic mouse
Alzheimer's disease
Retina
Tau pathology propagation

Discipline(s) HAL :

Sciences du Vivant [q-bio]
Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC]/Neurobiologie

Résumé en anglais : [en]

Neurofibrillary tangles (NFT), a neuronal lesion found in Alzheimer's disease (AD), are composed of fibrillary aggregates of modified forms of tau proteins. The propagation of NFT follows neuroanatomical pathways suggesting ...
Lire la suite >Neurofibrillary tangles (NFT), a neuronal lesion found in Alzheimer's disease (AD), are composed of fibrillary aggregates of modified forms of tau proteins. The propagation of NFT follows neuroanatomical pathways suggesting that synaptically connected neurons could transmit tau pathology by the recruitment of normal tau in a prion-like manner. Moreover, the intracerebral injection of pathological tau from AD brains induces the seeding of normal tau in mouse brain. Creutzfeldt-Jacob disease has been transmitted after ocular transplants of cornea or sclera and the scrapie agent can spread across the retino-tectal pathway after intraocular injection of scrapie mouse brain homogenates. In AD, a tau pathology has been detected in the retina. To investigate the potential risk of tau pathology transmission during eye surgery using AD tissue material, we have analysed the development of tau pathology in the visual pathway of mice models expressing murine tau, wild-type or mutant human tau after intraocular injection of pathological tau proteins from AD brains. Although these pathological tau proteins were internalized in retinal ganglion cells, they did not induce aggregation of endogenous tau nor propagation of a tau pathology in the retino-tectal pathway after a 6-month incubation period. These results suggest that retinal ganglion cells exhibit a resistance to develop a tau pathology, and that eye surgery is not a major iatrogenic risk of transmission of tau pathology, contrary to what has been observed for transmission of infectious prions in prion diseases.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Autres travaux scientifiques

Date de dépôt :

2024-01-16T00:39:24Z
2025-02-26T08:43:44Z